TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*3.A.11.1.1









DNA translocase. The three-layered DNA uptake machinery at the cell pole in competent Bacillus subtilis cells is a stable complex (Kaufenstein et al., 2011).

Bacteria
Firmicutes
ComEA-ComEC-ComFA of Bacillus subtilis
ComFA (463 aas; OTMSs; P39145)
ComEA (205 aas; 1 TMS; P39694)
ComeEC (776 aas; 12 TMSs; P39695)
*3.A.11.1.2









The single stranded DNA uptake competence transporter, ComEA/ComEC/ComFA (Cvitkovitch 2001; Claverys et al. 2006Claverys et al. 2006).

Bacteria
Firmicutes
ComEA/EC/FA of Streptococcus pneumoniae
ComEA (CelA) (216 aas; 1 TMS; Q8DQ41)
ComEC (CelB) (746 aas; ~10 TMSS; Q8DQ40)
ComFA (Competence DNA/RNA helicase protein)
(432 aas; 0-2 TMSs; Q8CWM9)
*3.A.11.1.3









The multicomponent DNA uptake competence transporter involving both competence and pilus biogenesis proteins (Averhoff, 2009; Karuppiah et al. 2013). 

Bacteria
Deinococcus-Thermus
Competence system of Thermus thermophilus (16 components)
ComEC (Q5SGW2)
ComEA (Q9EYM5)
DprA (Q8VRK4)
PilA1 (Q8KPZ4)
PilA2 (Q8KPZ3)
PilA3 (Q8KPZ2)
PilA4 (Q8KPZ0)
PilD (Q8VRL2)
PilF (Q8VRL1)
PilC (Q8VRL3)
PilQ (Q72IW4)
ComZ (Q8KPZ1)
PilM (Q8VRL8)
PilN (Q8VRL7)
PilO (F6DIG5)
PilW (F6DIG6)
*3.A.11.1.4









The phagosome escape and virulence competence system, ComEA-EC, FA, FC.  Functions in conjunction with the pseudopilus described under TC# 3.A.14.1.2 (Rabinovich et al., 2012).

Bacteria
Firmicutes
ComEA - EC; ComFA; ComFC of Listeria monocytogenes 
ComEA; DNA receptor (G2JTB5)
ComEB; unknown function (G2JTB4)
ComEC; channel (G2JNR0)
ComFA; DNA helicase (G2JSZ9)
ComFC; unknown function (G2JSZ8) 
*3.A.11.1.5









Putative competence system ComE1, ComE3, ComF1, ComFC plus pilin and additional coompetence-related proteins.  It is not sure that all of these proteins comprise a single system.  Their encoding genes are scattered thoughout the genome with only a few gene clusters.

Bacteria
Candidatus Saccharibacteria
Competince system of Candidatus Beckwithbacteria bacterium
*3.A.11.2.1









The single stranded DNA uptake competence transporter, ComEA/ComEC (Rec2)
Bacteria
Proteobacteria
ComEA/EC of Neisseria meningitidis
ComEA (148 aas; 1 TMS; A8V922)
ComEC (ComA) (691 aas; 8 YMSs; P51973)
*3.A.11.2.2









The single stranded DNA uptake competence transporter, ComEA/ComEC (Rec2)
Bacteria
Proteobacteria
ComEA/ComEC (Rec2) of Haemophilus influenzae
ComEA (112 aas; Q57134)
ComEC (Rec2) (788 aas; P44408)
*3.A.11.2.3









The single stranded DNA uptake competence transporter, ComEA/ComEC (Rec2)
Bacteria
Proteobacteria
ComEA/ComEC (Rec2) of Vibrio cholerae
ComEA (103 aas; 1 TMSs; A1EMW4)
ComEC (Rec2) (752 aas; 11 TMSs; A6XWX0)
*3.A.11.3.1









The competence channel protein, ComEC. It might be energized by the helicase, PriA instead of the ComFA protein in B. subtilis. No ComEA homologue has been identified in H. pylori (Stingl et al., 2010; K. Stingl, personal communication).

Bacteria
Proteobacteria
ComEC (ComE3) and PriA of Helicobacter pylori
ComEC (O25915)
PriA (Q9ZKE4)