TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*3.A.12.1.1









Septum DNA translocation pore protein SpoIIIE. SpoIIIE forms DNA-conducting channels across the two lipid bilayers of the septum (Burton et al., 2007). The dynamic assembly of SpoIIIE mediates septal membrane fission during Bacillus subtilis sporulation (Fleming et al., 2010).  Directionality of DNA pumping is probably a result of asymmetic chromosomal distrbution of SpoIIIE Recognition Sequences in the DNA.  Since SpoIIIE can strip proteins off the chromosome during translocation, SpoIIIE may interact with the DNA beyond it's binding sites (Higgins and Dworkin 2012).

Bacteria
Firmicutes
SpoIIIE of Bacillus subtilis
*3.A.12.1.2









Cell division protein, FtsK. FtsK lacking its integral membrane domain catalyzes fully efficient chromosome dimer resolution (Dubarry and Barre, 2010).  Its topology has been examined (Berezuk et al. 2014).

Bacteria
Proteobacteria
FtsK of E. coli
*3.A.12.1.3









SpoIIIE/FtsK homologue of 948 aas

Bacteria
Spirochaetes
FtsK homologue of Leptospira interrogans
*3.A.12.1.4









Cell division DNA translocase, FtsK of 917 aas and 4 TMSs (Bush et al. 2015).

Bacteria
Actinobacteria
FtsK of Streptomyces coelicolor
*3.A.12.1.5









DNA translocase, SftA (YtpS; YtpT) of 952 aas.  Required for the accurate completion of chromosome partitioning, in part by promoting efficient resolution of chromosome dimers, before the formation of the division septum. Binds to DNA in a non-specific manner. Shows ATPase activity. Not required for cytokinesis (Biller and Burkholder 2009; Kaimer et al. 2009).

Bacteria
Firmicutes
SftA of Bacillus subtilis
*3.A.12.2.1









The major protein required for plasmid transfer, Tra
Bacteria
Actinobacteria
Tra of Streptomyces lividans
*3.A.12.3.1









The DNA-binding translocating ATPase, TraB (translocates unprocessed plasmid DNA at the hyphal tip in a conjugation-like process) (Reuther et al, 2006).
Bacteria
Actinobacteria
TraB of plasmid pSG5 of Streptomyces ghanaensis
(O70031)
*3.A.12.3.2









The DNA-binding translocating ATPase, TraB (translocates unprocessed plasmid DNA at the hyphal tip in a conjugation-like process) (Reuther et al, 2006).
Bacteria
Actinobacteria
TraB of plasmid pSV of Streptomyces ghanaensis
(Q3LAJ2)