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3.A.19.1.3
Get3 ATPase homologue of 349 aas and 0 TMSs that drives the insertion of tail anchored (TA) proteins into the endoplasmic reticulum membrane.  The 3-d structure of the tetramer has been solved (Suloway et al. 2012). The tetramer generates a hydrophobic chamber that probably binds the single C-terminal TMS of the TA protein.

Accession Number:Q58542
Protein Name:Putative arsenical pump-driving ATPase
Length:349
Molecular Weight:39919.00
Species:Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) [243232]
Substrate tail anchored (TA) protein

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSKIKDSIN SLRGITEKKL EKKDGTKYIM FGGKGGVGKT TMSAATGVYL AEKGLKVVIV 
61:	STDPAHSLRD IFEQEFGHEP TKVKGYDNLY VVEIDPQKAM EEYKEKLKAQ IEENPFLGEM 
121:	LEDQLEMAAL SPGTDESAAF DVFLKYMDSN EFDVVIFDTA PTGHTLRFLG MPEVMDKYMT 
181:	KLIKLRKQMS GFMKMMKKLL PFGGKDEDID YDKMLEELEK MKERIVRARN ILSDPERTAF 
241:	RLVVIPEEMS ILESERAMKA LQKYGIPIDA VIVNQLIPED VQCDFCRARR ELQLKRLEMI 
301:	KEKFGDKVIA YVPLLRTEAK GIETLKQIAK ILYGEEEKEE QKIEQKVGQ