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3.A.19.1.4
ArsA1 of 777 aas.  ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the chloroplast. It is required for the accumulation of TOC34, an essential component of the outer chloroplast membrane translocon (TOC) complex (Formighieri et al. 2013, Maestre-Reyna et al. 2017). ArsA1 recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets the protein to the chloroplast, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis (Maestre-Reyna et al. 2017). Both ArsA proteins exhibit oxyanion-independent ATPase activity, but co-expression of ArsA proteins with TA-transmembrane regions showed not only that the former interact with the latter, but that ArsA1 does not share the same ligand specificity as ArsA2. ArsA1 mainly carries TA-proteins to the chloroplast, while ArsA2 carries them to the endoplasmic reticulum (Maestre-Reyna et al. 2017).

Accession Number:A8JGB0
Protein Name:ATPase ARSA1
Length:777
Molecular Weight:82383.00
Species:Chlamydomonas reinhardtii [3055]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

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FASTA formatted sequence
1:	MALASGNRLG SARGQTCADA SGRVAPRLLS RACSGSPLAL GVLACLGAAS SVKPHPRLPA 
61:	TTSAASAPLP ARGPAPCAAV PTVVTPDNAT GVFEELAAGQ QRKYIMISGK GGVGKTSLSA 
121:	SLAVKLAAAG HTTLVVSTDP AHSLSDSLAQ DVSGGRPVLL QGTDLPLWGL EIDPEEAKRE 
181:	FFEGSGAGQD GEAGGPSAAS QVSDFMNRMG MGFVIDQLKE LKLGELLNTP PPGLDEAVAI 
241:	AKVVQFVQAA EYARFSRIVF DTAPTGHTLR LLALPDFVDA SLAKVIRLRK KLNGATSVVR 
301:	GLFGAGESQD EAVEKLELLQ QRVRMVKALF RDKTQTEFII ATIPTYLGVN ESSRLLQALR 
361:	AEQIPCKRII VNQIVGPQQG DAYLRMKMKD QIAALEMVAN DPGLRPLRKV IAPMVDVEVR 
421:	GVPALSYFGN VVWKDVYDQM NQGADRKFFL LGGKGGVGKT SCSSSLAVHF ANDGLPTLVV 
481:	STDPAHSLSD AFDQDLSGGS PVKITSPLGD ELPLWGLQLD PEQAKAELRA VLADDGGKKL 
541:	NETLDGLGLG VISDQLKDLQ LGELLDTPPP GVDEAIAIAK VVQFLKAPEY SHFKRIVFDT 
601:	APTGHTLRLL SLPDFLDASI GKLVRLRQKL SAATSAVKNL FSGGQPGEED VAVKRLEALQ 
661:	ASMEDAKAMF RNQQTTEFII VTIPTVMATA ESCRLASALQ HEGIPLKTII VNQVVQANAT 
721:	DKFLTARRAD QARALHHLEE DTGPDGLASL QLIKAPLCDL EVRGVPALSY FGNVVWK