TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.19.1.5
ArsA2 of 362 aas (see description for ArsA1 (TC# 3.A.19.1.4) which has a similar function, but instead of targetting the chloroplast, ArsA2 targets the ER.  It recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis (Maestre-Reyna et al. 2017). ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Accession Number:A8IXB8
Protein Name:ATPase ARSA2
Length:362
Molecular Weight:39538.00
Species:Chlamydomonas reinhardtii [3055]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAADMPDPTL QNVVDQKELK WIFVGGKGGV GKTTTSSSLA VALAESGTRN RVLIISTDPA 
61:	HNLSDAFRQK FTKTPTLVNG FTNLFAMEVD PQPDIGEMEQ LEWAQDSFLT ELAGSIPGID 
121:	EAMSFAEVMK QVQTMDYDTI VFDTAPTGHT LRLLNFPTIL EKGLSKLVAL KGAMGGMMGQ 
181:	VTRMLGGMAG GGEGAADLPD QLLGKVEGML DVVRKVSAQF KDPLLTTFVA VCIPEFLSLY 
241:	ETERLVQELA KFEIDCRNIV INQIIFPESV GGSRLLDARV RMQQKYLDQF YELYEDFHIL 
301:	QLPLLEEEVR GPEALKAFAV NLLKPYVPAP PTDAAARQAA LVSEVAALKK RVAELEAALA 
361:	KK