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3.A.3.5.16
The transferable, plasmid-localized, copper resistance (efflux) ATPase, TcrB (50% identical to 3.A.3.5.2) (Hasman, 2005)

Accession Number:Q8VPE6
Protein Name:Cation-transporting ATPase aka TcrB
Length:710
Molecular Weight:76238.00
Species:Enterococcus faecium (Streptococcus faecium) [1352]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

Pfam: PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (2)

[1] “tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance.”  Hasman H.et.al.   11959576
[2] “The tcrB gene is part of the tcrYAZB operon conferring copper resistance in Enterococcus faecium and Enterococcus faecalis.”  Hasman H.et.al.   16151212

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MRNNKKHSSH SHHNHGDMEH SKHDHNEMEH SQMDHSKMNH SAMDHSKMNH SQMDHSEMDH 
61:	GAMGGHAHHH HGSFKEIFLK SLPLGIAILL ITPMMDIQLP FQIIFPYADV VAAVLATILY 
121:	IYGGKPFYMG AKDEFNSKAP GMMSLITLGI TVSYAYSVYA VAARYVTGEH VMDFFFEFAT 
181:	LILIMLLGHW IEMKALGEAG DAQKALAELV PKDAHVVLED DSIETRPVSE LQVGDVIRVQ 
241:	AGENVPADGI IIRGESRVNE ALVTGESKPI EKNPGDEVIG GSTNGGGVLY VEIKQTGDKS 
301:	FISQVQALIS QAQGQSSRAE NLAQKVAGWL FYIAVIVALI ALVIWMIIAD VPTAVIFTVT 
361:	TLVIACPHAL GLAIPLVTAR STSLGASRGL LVKDRDALEL TTNADVMVLD KTGTLTTGEF 
421:	KVLDVELFND KYTKDEIVAL LSGIEGGSSH PIAQSIISYA EQQGIRPVSF DSIDVISGAG 
481:	VEGQANGHRY QLISQKAYRR NLDMDIPKGA TLSVLVENDE AIGAVALGDE LKPTSKDLIQ 
541:	ALKKNKIQPI MATGDNEKAA QGTAEILGID YLANQSPQDK YELVEKLKAE GKKVIMVGDG 
601:	VNDAPSLALA DVGIAVGAGT QVALDSADVI LTQSDPGDIE SFIELAQKTT RKMKENLVWG 
661:	AGYNFIAIPI AAGILAPIGI TLSPAVGAVL MSLSTVIVAI NAMTLKLDPK