TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.3.6.12
The Cd2+/Pb2+ resistance P-type ATPase, CadA2; induced by Zn2+, Cd2+, Pb2+, Ni2+, Co2+ and Hg2+ (Leedjarv et al., 2007)

Accession Number:Q88CP1
Protein Name:CadA-2 aka Cadmium translocating P-type ATPase
Length:750
Molecular Weight:79329.00
Species:Pseudomonas putida (strain KT2440) [160488]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate H+, Zn2+, Cd2+, Pb2+, Ni2+, Co2+, Hg2+

Cross database links:

eggNOG: COG2217
HEGENOM: HBG507745
RefSeq: NP_747240.1   
Entrez Gene ID: 1041793   
Pfam: PF00122    PF00702   
KEGG: ppu:PP_5139   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0005261 F:cation channel activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0030001 P:metal ion transport

References (1)

[1] “Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.”  Nelson K.E.et.al.   12534463

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNQPVSHEHK HPHDHAHGDD DHGHAAHGHS CCGAKAAPPL VQLSETASAQ AQLSRFRIEA 
61:	MDCPTEQTLI QDKLSKLAGI EQLEFNLINR VLGVRHTLDG TADIERAIDS LGMKAEPIAA 
121:	QDDGSASVPQ PAKAHWWPLA LSGVAAIAAE IVHFAALAPE WVVAGLALAA ILGCGLGTYK 
181:	KGWIALKNRN LNINALMSIA VTGAVLIGQW PEAAMVMVLF TVAELIEARS LDRARNAIGG 
241:	LMQLTPDMAT VQQADGQWRE LDVREVAIGA LVRVRPGERI GLDGEVTRGQ SSVDQAPITG 
301:	ESLPVEKGVG DKLFAGTINQ AGALEFRVTA AAGQSTLARI IKAVEEAQGA RAPTQRFVDR 
361:	FSRIYTPVVF AIALAVALIP PLFLAGAWFD WVYRALVLLV VACPCALVIS TPVTIVSGLA 
421:	AAARKGILIK GGVYLEGGRH LDFLALDKTG TITHGKPVQT DAKVLAPLFE DRAQALAASL 
481:	GERSDHPVSR AIAEFGKQQG LALSEVSDFV ALAGRGVRGV IAGEVYHLGN HRLVEELGLC 
541:	SPALEAQLDA LERQGKTVVL LLDRSGPLAL FAVADTVKDS SRQAIAELHQ LGIKTVMLTG 
601:	DNPHTAQAIA AVVGIDRAEG NLLPADKLKT IEALYAQGHR VGMVGDGIND APALARAEIG 
661:	FAMAAAGTDT AIETADVALM DDDLRKIPAF VRLSRQSAAI LMQNIVLALG IKAIFLAITF 
721:	AGMATMWMAV FADMGVSLLV VFNGLRLLRK