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3.A.5.1.4
The general secratory pathway core components, SecYEGA. There are two cardiolipin (CL) binding sites on the surface of the transmembrane parts of SecY, and these two sites account for the preponderance of functional CL binding to SecYEG. They mediate the roles in ATPase and protein transport activity and confer PMF stimulation of protein transport. It is suggested that the apparent transient nature of the CL interaction might facilitate proton exchange with the Sec machinery, and thereby stimulate protein transport (Corey et al. 2018).

Accession Number:Q9X1I9
Protein Name:Protein translocase subunit SecY
Length:431
Molecular Weight:48170.00
Species:Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [243274]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWQAFKNAFK IPELRDRIIF TFLALIVFRM GIYIPVPGLN LEAWGEIFRR IAETAGVAGI 
61:	LSFYDVFTGG ALSRFSVFTM SVTPYITASI ILQLLASVMP SLKEMLREGE EGRKKFAKYT 
121:	RRLTLLIGGF QAFFVSFSLA RSNPDMVAPG VNVLQFTVLS TMSMLAGTMF LLWLGERITE 
181:	KGIGNGISIL IFAGIVARYP SYIRQAYLGG LNLLEWIFLI AVALITIFGI ILVQQAERRI 
241:	TIQYARRVTG RRVYGGASTY LPIKVNQGGV IPIIFASAIV SIPSAIASIT NNETLKNLFR 
301:	AGGFLYLLIY GLLVFFFTYF YSVVIFDPRE ISENIRKYGG YIPGLRPGRS TEQYLHRVLN 
361:	RVTFIGAVFL VVIALLPYLV QGAIKVNVWI GGTSALIAVG VALDIIQQME THMVMRHYEG 
421:	FIKKGKIRGR R