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3.D.2.3.1
H+-translocating transhydrogenase

Accession Number:P11024
Protein Name:NNTM aka NNT
Length:1086
Molecular Weight:113854.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2 / Matrix side3
Substrate H+

Cross database links:

eggNOG: maNOG11851
RefSeq: NP_776368.1   
Entrez Gene ID: 280878   
Pfam: PF01262    PF05222    PF02233   
KEGG: bta:280878   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0008750 F:NAD(P)+ transhydrogenase (AB-specific) acti...
GO:0055114 P:oxidation reduction
GO:0015992 P:proton transport

References (6)

[1] “Amino acid sequence of the signal peptide of mitochondrial nicotinamide nucleotide transhydrogenase as determined from the sequence of its messenger RNA.”  Yamaguchi M.et.al.   3196335
[2] “The primary structure of the mitochondrial energy-linked nicotinamide nucleotide transhydrogenase deduced from the sequence of cDNA clones.”  Yamaguchi M.et.al.   3277960
[3] “Characterization of the substrate-binding sites of the mitochondrial nicotinamide nucleotide transhydrogenase.”  Wakabayashi S.et.al.   3325062
[4] “Amino acid sequence of the NAD (H)-binding region of the mitochondrial nicotinamide nucleotide transhydrogenase modified by N,N'-dicyclohexylcarbodiimide.”  Wakabayashi S.et.al.   3426633
[5] “Mitochondrial energy-linked nicotinamide nucleotide transhydrogenase. Membrane topography of the bovine enzyme.”  Yamaguchi M.et.al.   2005110
[6] “Crystal structure of transhydrogenase domain III at 1.2 A resolution.”  Prasad G.S.et.al.   10581554
Structure:
1D4O     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANLLKTVVT GCSCPFLSNL GSCKVLPGKK NFLRTFHTHR ILWCSAPVKP GIPYKQLTVG 
61:	VPKEIFQNEK RVALSPAGVQ ALVKQGFNVV VESGAGEASK FSDDHYRAAG AQIQGAKEVL 
121:	ASDLVVKVRA PMLNPTLGVH EADLLKTSGT LISFIYPAQN PDLLNKLSKR KTTVLAMDQV 
181:	PRVTIAQGYD ALSSMANIAG YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL 
241:	ASAGAAKSMG AIVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE 
301:	MKLFAQQCKE VDILISTALI PGKKAPILFN KEMIESMKEG SVVVDLAAEA GGNFETTKPG 
361:	ELYVHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS PDKDNFYFEV KDDFDFGTMG 
421:	HVIRGTVVMK DGQVIFPAPT PKNIPQGAPV KQKTVAELEA EKAATITPFR KTMTSASVYT 
481:	AGLTGILGLG IAAPNLAFSQ MVTTFGLAGI VGYHTVWGVT PALHSPLMSV TNAISGLTAV 
541:	GGLVLMGGHL YPSTTSQGLA ALATFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL 
601:	PAGTFVGGYL ASLYSGYNIE QIMYLGSGLC CVGALAGLST QGTARLGNAL GMIGVAGGLA 
661:	ATLGGLKPCP ELLAQMSGAM ALGGTIGLTI AKRIQISDLP QLVAAFHSLV GLAAVLTCIA 
721:	EYIIEYPHFA TDAAANLTKI VAYLGTYIGG VTFSGSLVAY GKLQGILKSA PLLLPGRHLL 
781:	NAGLLAGSVG GIIPFMMDPS FTTGITCLGS VSALSAVMGV TLTAAIGGAD MPVVITVLNS 
841:	YSGWALCAEG FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG 
901:	KPMEISGTHT EINLDNAIDM IREANSIIIT PGYGLCAAKA QYPIADLVKM LSEQGKKVRF 
961:	GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINHDFPDT DLVLVIGAND TVNSAAQEDP 
1021:	NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA AVDNPIFYKP NTAMLLGDAK KTCDALQAKV 
1081:	RESYQK