TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*3.D.7.1.1









H2:heterodisulfide oxidoreductase, HHO. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008; Welte and Deppenmeier 2013).  The HdrD/E-type heterodisulfide reductase probably can function independently of the other subunits ().

Archaea
Euryarchaeota
HHO of Methanosarcina mazei Göl
VhoA: (CAA58114)
VhoG: (CAA58113)
VhoC: (CAA58115)
HdrD: (gbY09870)
HdrE: (gbY09870)
*3.D.7.1.2









Putative heterodisulfide oxidoreductase, HdrDE (Pires et al. 2003). HdrD, 423 aas and 1 TMS; HdrE, 394 aas and 6 TMSs.

Bacteria
Proteobacteria
HdrDE of Desulfovibrio desulfuricans
*3.D.7.1.3









Putative heterodisulfide reductase, HdrDE (Pires et al. 2003). HdrD, 663 aas and 6 TMSs; HdrE, 392 aas and 6 TMSs.

Bacteria
Chlorobi
HdrDE of Chlorobium phaeobacteroides
*3.D.7.2.1









Membrane-bound H2 oxidizing hydrogenase, HydAB (Guiral et al., 2005). HydC has not been identified, but adjacent to hydB is an open reading frame (ORF; AAC07057; 226aas) showing similarity to cytochromes that could be HydC.

Bacteria
Aquificae
HydAB of Aquifex aeolicus
HydA (large subunit; 564 aas) (AAC07046)
HydB (small subunit; 349 aas) (AAC07047)
*3.D.7.2.2









Membrane-bound Ni/Fe-hydrogenase complex, HydABC (Simon et al., 2008). HydC (P31875) resembles 5.A.3.5.1 (e-6), 5.A.3.2.1 (e-5), and 3.D.7.1.1 (e-4). Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008).

Bacteria
Proteobacteria
HydABC of Wolinella succinogenes
HydA (P31884)
HydB (P31883)
HydC (P31875)
*3.D.7.2.3









Hydrogenase HyaABCDEF, important for H2 oxidation during fermentation (Zbell and Maier 2009).

Bacteria
Proteobacteria
HyaABCDEF of Salmonella enterica suspecies enterica serovar Typhimurium
HyaA (367 aas, 4 TMSs)
HyaB (600 aas, 0 TMSs)
HyaC (347 aas, 4 TMSs)
HyaD (198 aas, 0 TMSs)
HyaE (134 aas, 0 TMSs)
HyaF (353 aas, 0 TMSs)