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3.E.1.4.2
Retinal binding protein, Neurospora Opsin-1, NOP-1 (Bieszke et al. 1999; Bieszke et al. 2007).

Accession Number:Q9UW81
Protein Name:NOP-1
Length:304
Molecular Weight:33487.00
Species:Neurospora crassa [5141]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

eggNOG: fuNOG09587
RefSeq: XP_959421.1   
Entrez Gene ID: 3875568   
Pfam: PF01036   
BioCyc: NCRA-XX3-01:NCRA-XX3-01-000024-MONOMER   
KEGG: ncr:NCU10055   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005503 F:all-trans retinal binding
GO:0005216 F:ion channel activity
GO:0009881 F:photoreceptor activity
GO:0006811 P:ion transport
GO:0007602 P:phototransduction
GO:0018298 P:protein-chromophore linkage

References (5)

[1] “The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins.”  Bieszke J.A.et.al.   10393943
[2] “The genome sequence of the filamentous fungus Neurospora crassa.”  Galagan J.E.et.al.   12712197
[3] “A eukaryotic protein, NOP-1, binds retinal to form an archaeal rhodopsin-like photochemically reactive pigment.”  Bieszke J.A.et.al.   10571987
[4] “Photochemical reaction cycle and proton transfers in Neurospora rhodopsin.”  Brown L.S.et.al.   11435422
[5] “A Fourier transform infrared study of Neurospora rhodopsin: similarities with archaeal rhodopsins.”  Bergo V.et.al.   12403457

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIHPEQVADM LRPTTSTTSS HVPGPVPTVV PTPTEYQTLG ETGHRTLWVT FALMVLSSGI 
61:	FALLSWNVPT SKRLFHVITT LITVVASLSY FAMATGHATT FNCDTAWDHH KHVPDTSHQV 
121:	CRQVFWGRYV DWALTTPLLL LELCLLAGVD GAHTLMAIVA DVIMVLCGLF AALGEGGNTA 
181:	QKWGWYTIGC FSYLFVIWHV ALHGSRTVTA KGRGVSRLFT GLAVFALLLW TAYPIIWGIA 
241:	GGARRTNVDT EILIYTVLDL LAKPVFGFWL LLSHRAMPET NIDLPGYWSH GLATEGRIRI 
301:	GEED