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3.E.1.5.2
Learning/memory process protein of 704 aas and 7 N-terminal TMSs as the rhodopsin (Rh) domain with a C-terminal cyclic nucleotide phosphodiesterase (PDE) domain.  The Rh-PDE enzyme light-dependently decreases the concentrations of cyclic nucleotides such as cGMP and cAMP. Photoexcitation of purified full-length Rh-PDE yields an "M" intermediate with a deprotonated Schiff base; its recovery is much faster than that of the enzyme domain (Watari et al. 2019). Mechanistic insights into rhodopsin-mediated, light-dependent regulation of second-messenger levels have thus been revealed (Watari et al. 2019).

Accession Number:EGD79054.1
Protein Name:EGD79054.1 learning/memory process protein [Salpingoeca rosetta]
Length:705
Molecular Weight:
Species:Salpingoeca rosetta [946362]
Number of TMSs:5
Substrate

Cross database links:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGRKNAANSS MLQEASMNNY SMTSAASGAS SSGRGKRRAK TRNIAIASTK EVQWQGIFMI 
61:	IVWLCVMGSL IFFANPEASR RVFAKFSHLQ SFYGATSVAF AFATGLDILA YVNAVSDEKR 
121:	VLSGILAYVD GVACISYLSM ATLNLYFLVD STQGNPVWLM RYAEWIITCP TLLYWCGLAS 
181:	RADRSSVSDI ATADALLLAG GALSSILPSW PAFFVFAGSF ATYIYVMLHM WGMFGKAMQP 
241:	DFQPPPPLPR HALHLLRCEI VMSWSIFPLV EFLRRQGYID FQVGEAMNCV ADYAAKVGLA 
301:	MIMVNCNLEQ INALRVQQMH SALTGMLKVM RKTNLSSSRM AQLDGVDDDV KSWIMNEFSG 
361:	STDGKGGDDA KAQQRARGRK GHSAAMDAEK LAASSLFTWD FDALDKSDED LTAVCVRVFQ 
421:	ELHVIEQFNI DEKKLRKWLQ KVRTQYNKNP FHNWRHAVMV LHTTYLLLTS VATEFITEVE 
481:	LLAMLIAALS HDLDHNGLTN AFHINSRSEL ALVYNDQSVL ENHHSHLAFE ILLEKGCNVV 
541:	ENLDEDEFKR LRAVIINCIL NTDMATHHTK LSKMEEVNRL GGFINLAENN DQRLFVLAVL 
601:	LHTADLHNPI KPFESNKRWS ARLQKEFNNQ VELEAKMNLP SLPFMRGNDE ESLAKGEIGF 
661:	INFVVKPWHQ QLSQAFPKLD FLLDTIDANL AEWKAIAESY RQMH