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3.E.1.7.3
Channelrhodopsin-2 light-gated ion channel. A 6Å projection map is available (Müller et al., 2011). Glutamate residue-97 lies in the outer pore where it interacts with a cation to facilitate dehydration. This residue is also the primary binding target of Gd3+ (Tanimoto et al., 2012).

Accession Number:B4Y105
Protein Name:Channelrhodopsin-2
Length:747
Molecular Weight:77829.00
Species:Volvox carteri f. nagariensis [3068]
Number of TMSs:7
Substrate ions

Cross database links:

Pfam: PF01036   

Gene Ontology

GO:0016020 C:membrane
GO:0005216 F:ion channel activity

References (1)

[1] “Channelrhodopsins of Volvox carteri Are Photochromic Proteins That Are Specifically Expressed in Somatic Cells under Control of Light, Temperature, and the Sex Inducer.”  Kianianmomeni A.et.al.   19641026

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDHPVARSLI GSSYTNLNNG SIVIPSDACF CMKWLKSKGS PVALKMANAL QWAAFALSVI 
61:	ILIYYAYATW RTTCGWEEVY VCCVELTKVV IEFFHEFDEP GMLYLANGNR VLWLRYGEWL 
121:	LTCPVILIHL SNLTGLKDDY NKRTMRLLVS DVGTIVWGAT AAMSTGYIKV IFFLLGCMYG 
181:	ANTFFHAAKV YIESYHTVPK GLCRQLVRAM AWLFFVSWGM FPVLFLLGPE GFGHLSVYGS 
241:	TIGHTIIDLL SKNCWGLLGH FLRLKIHEHI LLYGDIRKVQ KIRVAGEELE VETLMTEEAP 
301:	DTVKKSTAQY ANRESFLTMR DKLKEKGFEV RASLDNSGID AVINHNNNYN NALANAAAAV 
361:	GKPGMELSKL DHVAANAAGM GGIADHVATT SGAISPGRVI LAVPDISMVD YFREQFAQLP 
421:	VQYEVVPALG ADNAVQLVVQ AAGLGGCDFV LLHPEFLRDK SSTSLPARLR SIGQRVAAFG 
481:	WSPVGPVRDL IESAGLDGWL EGPSFGLGIS LPNLASLVLR MQHARKMAAM LGGMGGMLGS 
541:	NLMSGSGGVG LMGAGSPGGG GGAMGVGMTG MGMVGTNAMG RGAVGNSVAN ASMGGGSAGM 
601:	GMGMMGMVGA GVGGQQQMGA NGMGPTSFQL GSNPLYNTAP SPLSSQPGGD ASAAAAAAAA 
661:	AAATGAASNS MNAMQAGGSV RNSGILAGGL GSMMGPPGAP AAPTAAATAA PAVTMGAPGG 
721:	GGAAASEAEM LQQLMAEINR LKSELGE