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3.E.1.7.4
Channelopsin, MChR1 (Govorunova et al., 2011). In another channelrhodopsin (CrChR2) of this family, an E97A mutation in TMS 2 prevents high affiinity binding of the inhibitor, Gd3+ and interfers with photocurrent, but this ChR1 with an alanine at this position, has low affininty for Gd3+ but normal photocurrent (Watanabe et al. 2016).

Accession Number:F8UVI5
Protein Name:Channelopsin 1
Length:593
Molecular Weight:65743.00
Species:Mesostigma viride [41882]
Number of TMSs:8
Substrate H+

Cross database links:

Pfam: PF01036   

Gene Ontology

GO:0016020 C:membrane
GO:0005216 F:ion channel activity

References (1)

[1] “New Channelrhodopsin with a Red-Shifted Spectrum and Rapid Kinetics from Mesostigma viride.”  Govorunova E.G.et.al.   21693637

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPPTSPTPD TGHDTPDTGH DTGGHGAVEI CFAPCEEDCV TIRYFVENDF EGCIPGHFDQ 
61:	YSSHGSLHDI VKAALYICMV ISILQILFYG FQWWRKTCGW EVWFVACIET SIYIIAITSE 
121:	ADSPFTLYLT NGQISPQLRY MEWLMTCPVI LIALSNITGM AEEYNKRTMT LLTSDVCCIV 
181:	LGMMSAASKP RLKGILYAVG WAFGAWTYWT ALQVYRDAHK AVPKPLAWYV RAMGYVFFTS 
241:	WLTFPGWFLL GPEGLEVVTG TVSTLMHACS DLISKNLWGF MDWHLRVLVA RHHRKLFKAE 
301:	EEHALKKGQT LEPGMPRSTS FVRGLGDDVE IDPSYELYRL KRQNHPEYFL SPAQTPRRGP 
361:	SFDKRTSFEM DGGKNGMLQM MPVTGMGMGM GMGMGGGKTV LFLDYTGGGY VSFFEQQLSN 
421:	MGVNVTKCWS DDDMYNTAGV ANVKQLFHFA MIPNNALGGQ MVMDLRGTGL LVVAYGPEPP 
481:	MPGMGQDEFV PLQMPGVPYD ESILHNLVMR HAITQGLGMN GMQGNMGQQQ QMMGMQGNMN 
541:	GMQGNMNGMQ GNMNGMQGNM SGMQGNMNGM QGNSGMNQGW NNQGFTNTGA FGY