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4.A.1.1.10
The α-glucoside-specific IICB, AglB (transports glucose, methyl-α-glucoside, maltitol, isomaltose, trehalulose α(1→1), turanose α(1→3), maltulose α(1→4), leucrose α(1→5), and palatinose α(1→6), but not sucrose (most resembles 4.A.1.1.4 and 4.A.1.1.8) (Pikis et al., 2006)

Accession Number:Q9AGA7
Protein Name:Glucose/?-glucoside IICB complex
Length:540
Molecular Weight:58373.00
Species:Klebsiella pneumoniae [573]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glucose, Trehalulose, maltitol, isomaltose, Turanose, Maltulose, Leucrose, Palatinose, methyl-alpha-glucoside

Cross database links:

Pfam: PF00367    PF02378   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (2)

[1] “Metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae. Participation and properties of sucrose-6-phosphate hydrolase and phospho-alpha-glucosidase.”  Thompson J.et.al.   11473129
[2] “Phosphorylation and metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae.”  Thompson J.et.al.   11322729

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSQIQRFGG AMFTPVLLFP FAGIVVGIAI MLRNPMFVGE ALTAPDSLFA QIVHIIEEGG 
61:	WTVFRNMPLI FAVGLPIGLA KQAQGRACLA VLVSFLTWNY FINAMGMTWG HFFGVDFSAE 
121:	PTAGSGLTMI AGIKTLDTSI IGAIVISGLV TALHNRYFDK PLPVFLGIFQ GSSFVVIVAF 
181:	LAMIPCAWLT LLGWPKVQLG IESLQAFLRS AGALGVWVYI FLERILIPTG LHHFVYGPFI 
241:	FGPAVVEGGL QVYWAEHLQA FSQSTEPLKT LFPEGGFALH GNSKVFGSVG IALALYFTAA 
301:	PENRVKVAGL LIPATLTAML VGITEPLEFT FLFISPLLFA VHAVLAATMA TVMYICGVVG 
361:	NFGGGLLDQF LPQNWIPMFH HHASMMFIQI GIGLCFTALY FVVFRTLILR LNLKTPGREE 
421:	SEIKLYSKAD YQAARGKTTA AAAPETRLGQ AAGFLQALGG ADNIESINNC ATRLRIALVD 
481:	MAKTQSDDVF KALGAHGVVR RGNGIQVIVG LHVPQVRDQL ENLMKDSLST EHTTMTEAVS