TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


4.A.1.1.12
Maltose/Maltotriose PTS transporter, MalT (Shelburne et al., 2008) 631aas (68% identical to 4.A.1.1.11 from S. mutans

Accession Number:Q48WG5
Protein Name:MalT IICBA
Length:631
Molecular Weight:67799.00
Species:Streptococcus pyogenes serotype M1 [301447]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type IV membrane protein2
Substrate Maltose, Maltotriose

Cross database links:

HEGENOM: HBG571563
RefSeq: YP_283055.1   
Entrez Gene ID: 3571207   
Pfam: PF00358    PF00367    PF02378   
BioCyc: SPYO293653:M5005_SPY1692-MONOMER   
KEGG: spz:M5005_Spy_1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (1)

[1] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MINRITGAFY GVSSTMLADP EAKITSLLGT QMIVKDYFTS VLESPALNTG VFVGIIAGFV 
61:	GATAYNKYYN YRKLPEVLTF FNGKRFVPFV VILRSIFVAL ILVVVWPVIQ SGINSFGMWI 
121:	ASSQDSAPIL APFLYGTLER LLLPFGLHHM LTIPMNYTAL GGTYEVMTGA AAGTKVFGQD 
181:	PLWLAWVTDL VHLKGSDASA YSHLMDSVTP ARFKVGQMIG ATGTLMGVAL AMYRNVDADK 
241:	KHTYKMMFIS AAAAVFLTGV TEPLEYLFMF AAMPLYIVYA LVQGASFAMA DLVNLRVHSF 
301:	GNIELLTRTP MALKAGLGMD VINFVWVSVL FAVIMYFIAD MMIKKMHLAT AGRLGNYDAD 
361:	ILGDRNTQTR PTQVADSNSQ VVQIVNLLGG AGNIDDVDAC MTRLRVTVKD PAKVGAEDDW 
421:	KKAGAIGLIQ KGNGVQAVYG PKADILKSDI QDLLDSGALI PEVNMSQLTS KPTPAKDFKH 
481:	VTEDVLSVAD GMVLPITGVK DQVFAAKMMG DGFAVEPTHG NIYAPVAGLV TSVFPTKHAF 
541:	GLLTDNGLEV LVHVGLDTVA LNGVPFSVKV SEGQRVHAGD LLVVADLAAI KSAERETIIV 
601:	VAFTNTTEIQ DVTLTSLGAQ PAKTKVATVE L