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4.A.1.1.13
Glucose porter, GlcA (IICBA). Glucose uptake is inhibited by 2-deoxyglucose and methyl-β-D-glucoside (Christiansen and Hengstenberg, 1999).

Accession Number:Q57071
Protein Name:PTS system glucose-specific EIICBA component
Length:675
Molecular Weight:73111.00
Species:Staphylococcus carnosus (strain TM300) [396513]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Entrez Gene ID: 7551632   
Pfam: PF00358    PF00367    PF02378   
KEGG: sca:Sca_0999   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005355 F:glucose transmembrane transporter activity
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (4)

[1] “Cloning and sequencing of two genes from Staphylococcus carnosus coding for glucose-specific PTS and their expression in Escherichia coli K-12.”  Christiansen I.et.al.   8602153
[2] “Genome analysis of the meat starter culture bacterium Staphylococcus carnosus TM300.”  Rosenstein R.et.al.   19060169
[3] “Staphylococcal phosphoenolpyruvate-dependent phosphotransferase system -- two highly similar glucose permeases in Staphylococcus carnosus with different glucoside specificity: protein engineering in vivo?”  Christiansen I.et.al.   10537210
[4] “Regulation of the glucose-specific phosphotransferase system (PTS) of Staphylococcus carnosus by the antiterminator protein GlcT.”  Knezevic I.et.al.   10974121

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWKKFFGQLQ RIGKALMLPV AILPAAGLLL ALGNAFQGDA LQSLMPFIKA EGFQNVAKMM 
61:	EGAGGIIFDN LAIIFALGVA IGLASGDGVA AIAAFVGFIV LNKTMGMFLG VTPEKAADAA 
121:	TGFANVLGIP TLQTGVFGGI IIGALAAWCY NKFYNISLPS YLGFFAGKRF VPIMMATCSF 
181:	ILAFPMAIIW PSIQGGLNAF SEGLLASNTG LAVFLFGFIK RLLIPFGLHH IFHAPFWFEF 
241:	GSYKNAAGQI IHGDQRIFIE QIRDNVPLTA GKFMQGEFPV MMFGLPAAAL AIYQTAKKEN 
301:	KKVVAGLMLS GALTSFLTGI TEPLEFSFLF VAPLLFFIHA VLDGLSFLIL YLLDLHLGYT 
361:	FSGGFIDFFL LGILPNKTQW WLVIPVGLVY AAIYYIIFRF LIVKFNFKTP GREDKEVKSS 
421:	NVAASELPFK VLDAMGGKAN IKHLDACITR LRVEVNDKAK VDVQELKDLG ASGVLEVGNN 
481:	MQAIFGPKSD QIKHDMQQIM DGKITSPEET TVTEEGDKET AEIAAAGGGV VYAPIKGEVV 
541:	DISEVPDKVF SEKMMGDGIA IKPETGEVVA PFDGVVKMVF PTKHAIGLES KDGIELLIHF 
601:	GLETVKLEGK GFDILVKEND NIVLGQPLMK VDLDYIKEHA DSTITPIVVT NLNGRTMEVL 
661:	QHGEVKQGDK VILVK