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4.A.1.1.9
The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1)

Accession Number:P20166
Protein Name:PTS system, glucose-specific IICBA component aka EIICBA-Glc aka Glucose-permease IICBA component aka Phosphotransferase enzyme II, CBA component aka EC 2.7.1.69 aka EII-Glc/EIII-Glc
Length:699
Molecular Weight:75525.00
Species:Bacillus subtilis [1423]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

HEGENOM: HBG571563
RefSeq: NP_389272.1   
Entrez Gene ID: 939255   
Pfam: PF00358    PF00367    PF02378   
KEGG: bsu:BSU13890   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005355 F:glucose transmembrane transporter activity
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0015758 P:glucose transport
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (8)

[1] “Cloning and nucleotide sequence of the ptsG gene of Bacillus subtilis.”  Zagorec M.et.al.   1508157
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Phosphoenolpyruvate:sugar phosphotransferase system of Bacillus subtilis: nucleotide sequence of ptsX, ptsH and the 5'-end of ptsI and evidence for a ptsHI operon.”  Gonzy-Treboul G.et.al.   2497294
[4] “The glucose permease of the phosphotransferase system of Bacillus subtilis: evidence for IIGlc and IIIGlc domains.”  Gonzy-Treboul G.et.al.   1956301
[5] “The glucose permease of Bacillus subtilis is a single polypeptide chain that functions to energize the sucrose permease.”  Sutrina S.L.et.al.   2120236
[6] “Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution.”  Liao D.-I.et.al.   1911744
[7] “Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy.”  Fairbrother W.J.et.al.   1906345
[8] “High-resolution solution structure of Bacillus subtilis IIAglc.”  Chen Y.et.al.   9593197
Structure:
1AX3   1GPR     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFKALFGVLQ KIGRALMLPV AILPAAGILL AIGNAMQNKD MIQVLHFLSN DNVQLVAGVM 
61:	ESAGQIVFDN LPLLFAVGVA IGLANGDGVA GIAAIIGYLV MNVSMSAVLL ANGTIPSDSV 
121:	ERAKFFTENH PAYVNMLGIP TLATGVFGGI IVGVLAALLF NRFYTIELPQ YLGFFAGKRF 
181:	VPIVTSISAL ILGLIMLVIW PPIQHGLNAF STGLVEANPT LAAFIFGVIE RSLIPFGLHH 
241:	IFYSPFWYEF FSYKSAAGEI IRGDQRIFMA QIKDGVQLTA GTFMTGKYPF MMFGLPAAAL 
301:	AIYHEAKPQN KKLVAGIMGS AALTSFLTGI TEPLEFSFLF VAPVLFAIHC LFAGLSFMVM 
361:	QLLNVKIGMT FSGGLIDYFL FGILPNRTAW WLVIPVGLGL AVIYYFGFRF AIRKFNLKTP 
421:	GREDAAEETA APGKTGEAGD LPYEILQAMG DQENIKHLDA CITRLRVTVN DQKKVDKDRL 
481:	KQLGASGVLE VGNNIQAIFG PRSDGLKTQM QDIIAGRKPR PEPKTSAQEE VGQQVEEVIA 
541:	EPLQNEIGEE VFVSPITGEI HPITDVPDQV FSGKMMGDGF AILPSEGIVV SPVRGKILNV 
601:	FPTKHAIGLQ SDGGREILIH FGIDTVSLKG EGFTSFVSEG DRVEPGQKLL EVDLDAVKPN 
661:	VPSLMTPIVF TNLAEGETVS IKASGSVNRE QEDIVKIEK