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4.A.1.2.3
β-Glucoside [arbutin-salicin-cellobiose] (ASC) group translocator, AscF (Desai et al. 2010).

Accession Number:P24241
Protein Name:PTDA aka ASCF aka B2715
Length:485
Molecular Weight:51026.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate arbutin, salicin, Cellobiose

Cross database links:

Genevestigator: P24241
EchoBASE: EB0084
EcoGene: EG10086
eggNOG: COG1263
HEGENOM: HBG673521
RefSeq: AP_003282.1    YP_026182.1   
Entrez Gene ID: 947154   
Pfam: PF00367    PF02378   
BioCyc: EcoCyc:ASCF-MONOMER   
KEGG: ecj:JW5435    eco:b2715   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (5)

[1] “Nucleotide sequence, function, activation, and evolution of the cryptic asc operon of Escherichia coli K12.”  Hall B.G.et.al.   1630307
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKNYAALAR SVIAALGGVD NISAVTHCMT RLRFVIKDDA LIDSPTLKTI PGVLGVVRSD 
61:	NQCQVIIGNT VSQAFQEVVS LLPGDMQPAQ PVGKPKLTLR RIGAGILDAL IGTMSPLIPA 
121:	IIGGSMVKLL AMILEMSGVL TKGSPTLTIL NVIGDGAFFF LPLMVAASAA IKFKTNMSLA 
181:	IAIAGVLVHP SFIELMAKAA QGEHVEFALI PVTAVKYTYT VIPALVMTWC LSYIERWVDS 
241:	ITPAVTKNFL KPMLIVLIAA PLAILLIGPI GIWIGSAISA LVYTIHGYLG WLSVAIMGAL 
301:	WPLLVMTGMH RVFTPTIIQT IAETGKEGMV MPSEIGANLS LGGSSLAVAW KTKNPELRQT 
361:	ALAAAASAIM AGISEPALYG VAIRLKRPLI ASLISGFICG AVAGMAGLAS HSMAAPGLFT 
421:	SVQFFDPANP MSIVWVFAVM ALAVVLSFIL TLLLGFEDIP VEEAAAQARK YQSVQPTVAK 
481:	EVSLN