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4.A.1.2.4
Trehalose porter, TreB (IIBC) which can take up maltose by facilitated diffusion (Decker et al. 1999).  Can also transport sucrose at a low rate (Steen et al. 2014).

Accession Number:P36672
Protein Name:PTTB aka TREB aka B4240
Length:473
Molecular Weight:51081.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Trehalose

Cross database links:

Genevestigator: P36672
EchoBASE: EB2048
EcoGene: EG12127
eggNOG: COG1263
HEGENOM: HBG673521
RefSeq: AP_004738.1    NP_418661.1   
Entrez Gene ID: 948761   
Pfam: PF00367    PF02378   
BioCyc: EcoCyc:TREB-MONOMER    ECOL168927:B4240-MONOMER   
KEGG: ecj:JW4199    eco:b4240   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0015574 F:trehalose transmembrane transporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...
GO:0015771 P:trehalose transport

References (5)

[1] “Molecular analysis of treB encoding the Escherichia coli enzyme II specific for trehalose.”  Klein W.et.al.   7608078
[2] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMSKINQTDI DRLIELVGGR GNIATVSHCI TRLRFVLNQP ANARPKEIEQ LPMVKGCFTN 
61:	AGQFQVVIGT NVGDYYQALI ASTGQAQVDK EQVKKAARHN MKWHEQLISH FAVIFFPLLP 
121:	ALISGGLILG FRNVIGDLPM SNGQTLAQMY PSLQTIYDFL WLIGEAIFFY LPVGICWSAV 
181:	KKMGGTPILG IVLGVTLVSP QLMNAYLLGQ QLPEVWDFGM FSIAKVGYQA QVIPALLAGL 
241:	ALGVIETRLK RIVPDYLYLV VVPVCSLILA VFLAHALIGP FGRMIGDGVA FAVRHLMTGS 
301:	FAPIGAALFG FLYAPLVITG VHQTTLAIDL QMIQSMGGTP VWPLIALSNI AQGSAVIGII 
361:	ISSRKHNERE ISVPAAISAW LGVTEPAMYG INLKYRFPML CAMIGSGLAG LLCGLNGVMA 
421:	NGIGVGGLPG ILSIQPSYWQ VFALAMAIAI IIPIVLTSFI YQRKYRLGTL DIV