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4.A.1.2.7
N-Acetylmuramic acid porter, MurP (YfeV) (Dahl et al., 2004)

Accession Number:P77272
Protein Name:N-Acetylmuramic acid porter, MurP (YfeV)
Length:474
Molecular Weight:49802.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate N-acetylmuramic acid

Cross database links:

Genevestigator: P77272
EchoBASE: EB3915
EcoGene: EG14163
HEGENOM: HBG673521
RefSeq: AP_003023.1    NP_416924.1   
Entrez Gene ID: 946894   
Pfam: PF00367    PF02378   
BioCyc: EcoCyc:MONOMER0-5    ECOL168927:B2429-MONOMER   
KEGG: ecj:JW2422    eco:b2429   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (7)

[1] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.”  Dahl U.et.al.   15060041
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[6] “MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.”  Uehara T.et.al.   16452451
[7] “The transcriptional factors MurR and catabolite activator protein regulate N-acetylmuramic acid catabolism in Escherichia coli.”  Jaeger T.et.al.   18723630

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAKEISSELL NTILTRVGGP GNIASCGNCM TRLRLGVHDS SLVDPNIKTL EGVKGVILTS 
61:	DQVQVVFGPG KAHRAAKAMS ELLGEAPVQD AAEIAAQNKR QLKAKQTSGV QQFLAKFATI 
121:	FTPLIPGFIA AGLLLGIATL IATVMHVPAD AQGTLPDALN FMKVFSKGLF TFLVILVGYN 
181:	AAQAFGGTGV NGAIIAALFL LGYNPAATTG YYAGFHDFFG LPIDPRGNII GVLIAAWACA 
241:	RIEGMVRRFM PDDLDMLLTS LITLLITATL AYLIIMPLGG WLFEGMSWLF MHLNSNPFGC 
301:	AVLAGLFLIA VVFGVHQGFI PVYLALMDSQ GFNSLFPILS MAGAGQVGAA LALYWRAQPH 
361:	SALRSQVRGA IIPGLLGVGE PLIYGVTLPR MKPFVTACLG GAAGGLFIGL IAWWGLPMGL 
421:	NSAFGPSGLV ALPLMTSAQG ILPAMAVYAG GILVAWVCGF IFTTLFGCRN VNLD