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4.A.1.2.8
Trehalose porter, IIBC (TreP) (38% identical to 4.A.1.2.4) (Schöck and Dahl 1996; Ujiie et al. 2009).

Accession Number:P39794
Protein Name:PTS system, trehalose-specific IIBC component aka EIIBC-Tre aka Trehalose-permease IIBC component aka Phosphotransferase enzyme II, BC component aka EC 2.7.1.69 aka EII-Tre
Length:470
Molecular Weight:50000.00
Species:Bacillus subtilis [1423]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Trehalose

Cross database links:

HEGENOM: HBG673521
RefSeq: NP_388661.1   
Entrez Gene ID: 939188   
Pfam: PF00367    PF02378   
KEGG: bsu:BSU07800   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0015574 F:trehalose transmembrane transporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...
GO:0015771 P:trehalose transport

References (5)

[1] “Analysis of DNA flanking the treA gene of Bacillus subtilis reveals genes encoding a putative specific enzyme IITre and a potential regulator of the trehalose operon.”  Schoeck F.et.al.   8917076
[2] “Cloning and sequencing of a 40.6 kb segment in the 73 degrees-76 degrees region of the Bacillus subtilis chromosome containing genes for trehalose metabolism and acetoin utilization.”  Yamamoto H.et.al.   8969503
[3] “Cloning and sequencing of a 35.7 kb in the 70 degree-73 degree region of the Bacillus subtilis genome reveal genes for a new two-component system, three spore germination proteins, an iron uptake system and a general stress response protein.”  Yamamoto H.et.al.   9272861
[4] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[5] “Cleavage of trehalose-phosphate in Bacillus subtilis is catalysed by a phospho-alpha-(1-1)-glucosidase encoded by the treA gene.”  Helfert C.et.al.   7651129

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGELNKSARQ IVEAVGGAEN IAAATHCVTR LRFALIDESK VDQEMLDQID VVKGSFSTNG 
61:	QFQVVIGQGT VNKVYAELVK ETGIGESTKD EVKKASEKNM NPLQRAVKTL ADIFIPILPA 
121:	IVTAGLLMGI NNILTAEGIF FSTKSIVQVY PQWADLANMI NLIAGTAFTF LPALIGWSAV 
181:	KRFGGNPLLG IVLGVMLVHP DLLNAWGYGA AEQSGEIPVW NLFGLEVQKV GYQGQVLPIL 
241:	LASYMLAKIE VFLTKRTPEG IQLLVVAPIT LLLTGFASFI IIGPITFAIG NVLTSGLISV 
301:	FGSFAALGGL LYGGFYSALV ITGMHHTFLA VDLQLIGSKL GGTFLWPMLA LSNIAQGSAA 
361:	LAMMFIVKDE KQKGLSLTSG ISAYLGITEP AIFGVNLRYR FPFIIAMVSS GLAGMYISSQ 
421:	GVLASSVGVG GVPGIFSIMS QYWGAFAIGM AIVLIVPFAG TYAYARFKHK