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4.A.2.1.12
The mannitol/glucitol transporter, MtlA (IICBAMtl) (Kumar et al., 2011)

Accession Number:Q9KKQ7
Protein Name:PTS system mannitol-specific EIICBA component
Length:649
Molecular Weight:68674.00
Species:Vibrio cholerae [666]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate mannitol, Gluticol

Cross database links:

HEGENOM: HBG296680
Entrez Gene ID: 2612120   
Pfam: PF00359    PF02378    PF02302   
KEGG: vch:VCA1045   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phosphotransferase system

References (1)

[1] “DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.”  Heidelberg J.F.et.al.   10952301

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MISSDAKVKI QNFGRFLSNM VMPNIGAFIA WGFITALFIP TGWVPNETLA SLVGPMITYL 
61:	LPLLIGYTGG KLAGGERGAV VGAITTMGVI VGTDIPMFMG AMIVGPMGGW AIKAFDKKID 
121:	GKVRSGFEML VNNFSAGIIG MLCAIIAFFL IGPFVKVLSG ALAAGVNFLV TAHLLPLTSI 
181:	FVEPAKILFL NNAINHGIFS PLGIQQASET GQSIFFLIEA NPGPGLGILL AYMVFGKGTA 
241:	RQTAGGATII HFFGGIHEIY FPYILMNPRL ILAAIAGGMT GVFTLTVFNA GLVSPASPGS 
301:	IFAVLLMTNK GSILGVVCSI FAAAAVSFTV AALLMKAQTS TEQDGDKDAL VKATSIMQEM 
361:	KAGSKGQAAP TATQSKKIDM ANVQSIIVAC DAGMGSSAMG ASMLRKKIQE VGLPVTVTNM 
421:	AINSLPAHVD MVITHQDLTD RARQHAPNAE HISLNNFLDS ALYNQLVTQL LAAKRQAAND 
481:	SQLIKPSILA ANDDRYEVQQ PSVFQLQKEN IHLGLNAKNK EEAIRFAGNK LVELGYVHPE 
541:	YVDAMFEREK LVSTYLGESI AVPHGTVDAK DRVIKTGIVI CQYPQGVAFS EDSGDVAKLV 
601:	IGIAAKNDEH IQVITTITNA LDDPNAIDKL TSTKDVSDVL SILATSQAA