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4.A.2.1.3
The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) (Sampaio et al., 2004).  The phosphorylated product is hydrolyzed to manose-6-P and glycerate by MngB, an α-mannosidase.

Accession Number:P54745
Protein Name:2-O-alpha-mannosyl D-glycerate porter, MngA (HrsA)
Length:658
Molecular Weight:69668.00
Species:Escherichia coli [83333]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate 2-O-alpha-mannosyl D-glycerate

Cross database links:

Genevestigator: P54745
EchoBASE: EB3024
EcoGene: EG13235
eggNOG: COG1299
HEGENOM: HBG704192
DIP: DIP-9939N
RefSeq: AP_001368.1    NP_415259.1   
Entrez Gene ID: 945355   
Pfam: PF00359    PF02378    PF02302   
BioCyc: EcoCyc:HRSA-MONOMER    ECOL168927:B0731-MONOMER   
KEGG: ecj:JW0720    eco:b0731   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (5)

[1] “Isolation and characterization of the heat-responsive genes in Escherichia coli.”  Utsumi R.et.al.   9063979
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVLFYRAHWR DYKNDQVRIM MNLTTLTHRD ALCLNARFTS REEAIHALTQ RLAALGKISS 
61:	TEQFLEEVYR RESLGPTALG EGLAVPHGKT AAVKEAAFAV ATLSEPLQWE GVDGPEAVDL 
121:	VVLLAIPPNE AGTTHMQLLT ALTTRLADDE IRARIQSATT PDELLSALDD KGGTQPSASF 
181:	SNAPTIVCVT ACPAGIAHTY MAAEYLEKAG RKLGVNVYVE KQGANGIEGR LTADQLNSAT 
241:	ACIFAAEVAI KESERFNGIP ALSVPVAEPI RHAEALIQQA LTLKRSDETR TVQQDTQPVK 
301:	SVKTELKQAL LSGISFAVPL IVAGGTVLAV AVLLSQIFGL QDLFNEENSW LWMYRKLGGG 
361:	LLGILMVPVL AAYTAYSLAD KPALAPGFAA GLAANMIGSG FLGAVVGGLI AGYLMRWVKN 
421:	HLRLSSKFNG FLTFYLYPVL GTLGAGSLML FVVGEPVAWI NNSLTAWLNG LSGSNALLLG 
481:	AILGFMCSFD LGGPVNKAAY AFCLGAMANG VYGPYAIFAS VKMVSAFTVT ASTMLAPRLF 
541:	KEFEIETGKS TWLLGLAGIT EGAIPMAIED PLRVIGSFVL GSMVTGAIVG AMNIGLSTPG 
601:	AGIFSLFLLH DNGAGGVMAA IGWFGAALVG AAISTAILLM WRRHAVKHGN YLTDGVMP