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4.A.2.1.6
The mannose porter (ManP) (37% identical to 4.A.2.1.1). It is encoded in an operon with 3 genes:  manP-manA-yjdD, where manP codes for the IIBCA mannose transporter, manA codes for a mannose-6-P isomerase and YjdD  codes for a 5-formyltetrahydrofolate cyclo-ligase, characterized in B. anthrasis.  Expression of the operon is regulated by ManP and ManR, an activator, in response to external mannose (Sun and Altenbuchner 2010). 

Accession Number:O31645
Protein Name:Phosphotransferase system (PTS) mannose-specific enzyme IIBCA component
Length:650
Molecular Weight:69026.00
Species:Bacillus subtilis [1423]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mannose

Cross database links:

HEGENOM: HBG704192
RefSeq: NP_389083.2   
Entrez Gene ID: 936437   
Pfam: PF00359    PF02378    PF02302   
BioCyc: SUBTI:BSU12010-MONOMER   
KEGG: bsu:BSU12010   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (5)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[2] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706
[3] “Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis.”  Reizer J.et.al.   10627040
[4] “Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis.”  Turner M.S.et.al.   10960106
[5] “The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.”  Macek B.et.al.   17218307
Structure:
2R48     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKLLAITSCP NGIAHTYMAA ENLQKAADRL GVSIKVETQG GIGVENKLTE EEIREADAII 
61:	IAADRSVNKD RFIGKKLLSV GVQDGIRKPE ELIQKALNGD IPVYRSATKS ESGNHQEKKQ 
121:	NPIYRHLMNG VSFMVPFIVV GGLLIAVALT LGGEKTPKGL VIPDDSFWKT IEQIGSASFS 
181:	FMIPILAGYI AYSIADKPGL VPGMIGGYIA ATGSFYDSAS GAGFLGGIIA GFLAGYAALW 
241:	IKKLKVPKAI QPIMPIIIIP VFASLIVGLA FVFLIGAPVA QIFASLTVWL AGMKGSSSIL 
301:	LALILGAMIS FDMGGPVNKV AFLFGSAMIG EGNYEIMGPI AVAICIPPIG LGIATFLGKR 
361:	KFEASQREMG KAAFTMGLFG ITEGAIPFAA QDPLRVIPSI MAGSMTGSVI AMIGNVGDRV 
421:	AHGGPIVAVL GAVDHVLMFF IAVIAGSLVT ALFVNVLKKD ITASPVLSET APTSAPSEAA 
481:	AANEIKQPIQ SQKAEMSEFK KLTDIISPEL IEPNLSGETS DDIIDELIQK LSRRGALLSE 
541:	SGFKQAILNR EQQGTTAIGM NIAIPHGKSE AVREPSVAFG IKRSGVDWNS LDGSEAKLIF 
601:	MIAVPKESGG NQHLKILQML SRKLMDDNYR ERLLSVQTTE EAYKLLEEIE