TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*4.C.1.1.1









Putative fatty acid transporter, FatP4 (Hall et al., 2005)
Eukaryota
Metazoa
FatP4 of Mus musculus (O88562)
*4.C.1.1.2









Long chain fatty acid transporter, Fat1 of 669 aa and 2 TMSs with an Nin-Cin topology. Obermeyer et al. 2007 proposed that Fat1p has a third region, which binds to the membrane and separates the highly conserved residues comprising the two halves of the ATP/AMP motif. The proposed topology places the ATP/AMP and FATP/VLACS domains on the inner face of the plasma membrane. The carboxyl-terminal region of Fat1p, which interacts with ACSL, is likewise positioned on the inner face of the plasma membrane (Obermeyer et al. 2007).

Eukaryota
Fungi
Fat1 of Saccharomyces cerevisiae (P38225)
*4.C.1.1.3









Putative long chain fatty acid transporter Fat1
Bacteria
Actinobacteria
FAT1 of Mycobacterium tuberculosis (O05307)
*4.C.1.1.4









Long chain fatty acyl CoA synthase (ligase), (EC 6.2.1.3)
Bacteria
Proteobacteria
FadD of E. coli (P69451)
*4.C.1.1.5









Peroxysomal fatty acyl CoA synthase (ligase) or long chain fatty acid transporter-2, FATP2, of 620 aas and 2 TMSs. FATP2 may be a major apical proximal tubule nonesterified fatty acid transporter that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression (Khan et al. 2017).

Eukaryota
Metazoa
SLC27A2 of Homo sapiens
*4.C.1.1.6









Carnitine/crotonobetaine CoA synthase (ligase), CaiC (EC 6.3.2.)
Bacteria
Proteobacteria
CaiC of E. coli (P31552)
*4.C.1.1.7









4-Coumarate CoA synthase (ligase 2) (EC 6.2.1.12)
Eukaryota
Viridiplantae
4-Coumarate CoA ligase of Solanum tuberosum (P38165)
*4.C.1.1.8









Bile-acyl CoA synthetase/ Very long chain acyl CoA synthetase-related protein (Solute carrier family 27 member 5) (Gimeno, 2007)
Eukaryota
Metazoa
FatP5 of Mus musculus (Q4LDG0)
*4.C.1.1.9









Long-chain fatty acid trans-plasma membrane translocase or trapping enzyme, FATP1 (Insulin regulated). HIt has acyl-CoA ligase activity. (Martin et al., 2000; Hatch et al., 2002). FATP1 plays a role in porcine intramuscular preadipocytes proliferation and differentiation (Chen et al. 2017).

Eukaryota
Metazoa
SLC27A1 of Homo sapiens
*4.C.1.1.10









Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4).  FATP4 is one of a family of six transmembrane proteins that facilitate long- and very long-chain fatty acid uptake. FATP4 is expressed in several tissues, including skin. Mutations in human SLC27A4, which encodes FATP4, cause ichthyosis prematurity syndrome, characterized by a thick desquamating epidermis and premature birth ().

Eukaryota
Metazoa
SLC27A4 of Homo sapiens
*4.C.1.1.11









Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homologue 1) (VLCSH1) (hVLCS-H1)

Eukaryota
Metazoa
SLC27A6 of Homo sapiens
*4.C.1.1.12









Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (EC 6.2.1.-) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homologue 3) (VLCS-3)

Eukaryota
Metazoa
SLC27A3 of Homo sapiens
*4.C.1.1.13









Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homologue 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)

Eukaryota
Metazoa
SLC27A5 of Homo sapiens
*4.C.1.1.14









Long chain fatty acyl-CoA ligase (synthetase) (E.C. 6.2.1.3) (Pulsifer et al., 2012).

Eukaryota
Viridiplantae
LCFA ligase of Arabidopsis thaliana (Q9XIA9)
*4.C.1.1.15









Long chain fatty acyl-CoA ligase 2 of 744 aas.  May play a role in lauric acid transport and thioesterification (Visser et al. 2007).

Eukaryota
Fungi
Faa2 of Saccharomyces cerevisiae
*4.C.1.1.16









Bifunctional protein, Aas of 719 aas and 3 - 5 TMSs.  Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

Bacteria
Proteobacteria
Aas of E. coli
*4.C.1.1.17









The fatty acid transport protein-1, FATP-1 of 646 aas and from 1 to several TMSs. Expression levels of the encoding gene occurs in a tissue and gender-specific fashon (Song et al. 2008).

Eukaryota
Metazoa
FatP1 of Gallus gallus