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4.C.1.1.1
Putative fatty acid transporter, FatP4 (Hall et al., 2005)

Accession Number:Q91VE0
Protein Name:Long-chain fatty acid transport protein 4
Length:643
Molecular Weight:72319.00
Species: [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: Q91VE0
HEGENOM: HBG712034
RefSeq: NP_036119.1   
Entrez Gene ID: 26569   
Pfam: PF00501   
KEGG: mmu:26569   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005902 C:microvillus
GO:0004467 F:long-chain-fatty-acid-CoA ligase activity
GO:0000166 F:nucleotide binding
GO:0031957 F:very-long-chain-fatty-acid-CoA ligase activity
GO:0001676 P:long-chain fatty acid metabolic process
GO:0015909 P:long-chain fatty acid transport
GO:0001579 P:medium-chain fatty acid transport
GO:0043588 P:skin development
GO:0042760 P:very-long-chain fatty acid catabolic process

References (10)

[1] “Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase.”  Herrmann T.et.al.   11404000
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “A family of fatty acid transporters conserved from mycobacterium to man.”  Hirsch D.et.al.   9671728
[5] “Identification of the major intestinal fatty acid transport protein.”  Stahl A.et.al.   10518211
[6] “Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality.”  Gimeno R.E.et.al.   14512415
[7] “Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy.”  Herrmann T.et.al.   12821645
[8] “Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.”  Moulson C.L.et.al.   12697906
[9] “Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice.”  Hall A.M.et.al.   15653672
[10] “Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast.”  DiRusso C.C.et.al.   15699031

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLLGASLVGA LLFSKLVLKL PWTQVGFSLL LLYLGSGGWR FIRVFIKTVR RDIFGGMVLL 
61:	KVKTKVRRYL QERKTVPLLF ASMVQRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA 
121:	RGLASGNVVA LFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALRHCLD TSKARALIFG 
181:	SEMASAICEI HASLEPTLSL FCSGSWEPST VPVSTEHLDP LLEDAPKHLP SHPDKGFTDK 
241:	LFYIYTSGTT GLPKAAIVVH SRYYRMASLV YYGFRMRPDD IVYDCLPLYH SAGNIVGIGQ 
301:	CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE SRHKVRMALG 
361:	NGLRQSIWTD FSSRFHIPQV AEFYGATECN CSLGNFDSRV GACGFNSRIL SFVYPIRLVR 
421:	VNEDTMELIR GPDGVCIPCQ PGQPGQLVGR IIQQDPLRRF DGYLNQGANN KKIANDVFKK 
481:	GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLH MADVAVYGVE 
541:	VPGTEGRAGM AAVASPISNC DLESFAQTLK KELPLYARPI FLRFLPELHK TGTFKFQKTE 
601:	LRKEGFDPSV VKDPLFYLDA RKGCYVALDQ EAYTRIQAGE EKL