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4.C.1.1.2
Long chain fatty acid transporter, Fat1 of 669 aa and 2 TMSs with an Nin-Cin topology. Obermeyer et al. 2007 proposed that Fat1p has a third region, which binds to the membrane and separates the highly conserved residues comprising the two halves of the ATP/AMP motif. The proposed topology places the ATP/AMP and FATP/VLACS domains on the inner face of the plasma membrane. The carboxyl-terminal region of Fat1p, which interacts with ACSL, is likewise positioned on the inner face of the plasma membrane (Obermeyer et al. 2007).

Accession Number:P38225
Protein Name:Fat1 aka YBR041W aka YBR0411
Length:669
Molecular Weight:77141.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: P38225
eggNOG: fuNOG04525
HEGENOM: HBG712034
DIP: DIP-5048N
RefSeq: NP_009597.2   
Entrez Gene ID: 852329   
Pfam: PF00501   
KEGG: sce:YBR041W   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0031235 C:intrinsic to internal side of plasma membrane
GO:0005811 C:lipid particle
GO:0005777 C:peroxisome
GO:0042802 F:identical protein binding
GO:0005324 F:long-chain fatty acid transporter activity
GO:0031957 F:very-long-chain-fatty-acid-CoA ligase activity
GO:0015909 P:long-chain fatty acid transport
GO:0000038 P:very-long-chain fatty acid metabolic process

References (3)

[1] “Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids.”  Faergeman N.J.et.al.   9079682
[2] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY KEDWYIIPYF 
61:	LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP MAEKGEFQLE TFTYIETYNI 
121:	VLRLSHILHF DYNVQAGDYV AIDCTNKPLF VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL 
181:	KISNITQVFI DPDASNPIRE SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV 
241:	RTPLGLTDFK PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF 
301:	HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR YLLHTPISKY 
361:	EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA PFATTTFQKG DFGIGACRNY 
421:	GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK GFCEVAPVGE PGEMLMRIFF PKKPETSFQG 
481:	YLGNAKETKS KVVRDVFRRG DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV 
541:	EDQLTASNKE QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP 
601:	SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR YEVLTAADWE 
661:	AIDAQTIKL