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4.C.1.1.5
Peroxysomal fatty acyl CoA synthase (ligase) or long chain fatty acid transporter-2, FATP2, of 620 aas and 2 TMSs. FATP2 may be a major apical proximal tubule nonesterified fatty acid transporter that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression (Khan et al. 2017).

Accession Number:O14975
Protein Name:VLCS aka SLC27A2 aka FACVL1 aka VLACS aka FATP2
Length:620
Molecular Weight:70312.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: O14975 O14975
eggNOG: prNOG12818 COG0318
HEGENOM: HBG712034 HOG000044189
RefSeq: NP_001153101.1    NP_003636.2   
Entrez Gene ID: 11001   
Pfam: PF00501   
OMIM: 603247  gene
KEGG: hsa:11001    hsa:11001   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005782 C:peroxisomal matrix
GO:0005778 C:peroxisomal membrane
GO:0005524 F:ATP binding
GO:0004467 F:long-chain-fatty-acid-CoA ligase activity
GO:0050197 F:phytanate-CoA ligase activity
GO:0070251 F:pristanate-CoA ligase activity
GO:0000038 P:very-long-chain fatty acid metabolic process
GO:0005788 C:endoplasmic reticulum lumen
GO:0030176 C:integral to endoplasmic reticulum membrane
GO:0005779 C:integral to peroxisomal membrane
GO:0005792 C:microsome
GO:0005739 C:mitochondrion
GO:0015245 F:fatty acid transporter activity
GO:0031957 F:very long-chain fatty acid-CoA ligase activity
GO:0006699 P:bile acid biosynthetic process
GO:0001561 P:fatty acid alpha-oxidation
GO:0006635 P:fatty acid beta-oxidation
GO:0044539 P:long-chain fatty acid import
GO:0001676 P:long-chain fatty acid metabolic process
GO:0097089 P:methyl-branched fatty acid metabolic process
GO:0042760 P:very long-chain fatty acid catabolic process

References (12)

[1] “Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.”  Steinberg S.J.et.al.   10198260
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Analysis of the DNA sequence and duplication history of human chromosome 15.”  Zody M.C.et.al.   16572171
[4] “Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.”  Mihalik S.J.et.al.   11980911
[5] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[6] “Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.”  Steinberg S.J.et.al.   10198260
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “Analysis of the DNA sequence and duplication history of human chromosome 15.”  Zody M.C.et.al.   16572171
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.”  Mihalik S.J.et.al.   11980911
[11] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[12] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGQRR PARTILRAFL 
61:	EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL 
121:	WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY 
181:	YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ 
241:	RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 
301:	CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE 
361:	FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG 
421:	EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR 
481:	VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK 
541:	KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 
601:	MYVPMTEDIY NAISAKTLKL