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4.C.1.1.6
Carnitine/crotonobetaine CoA synthase (ligase), CaiC (EC 6.3.2.)

Accession Number:P31552
Protein Name:CaiC aka B0037
Length:517
Molecular Weight:58559.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Carnitine, Crotonobetaine

Cross database links:

Genevestigator: P31552
EchoBASE: EB1519
EcoGene: EG11558
eggNOG: COG0318
HEGENOM: HBG547964
DIP: DIP-9243N
RefSeq: AP_000701.1    NP_414579.4   
Entrez Gene ID: 944886   
Pfam: PF00501   
BioCyc: EcoCyc:CAIC-MONOMER    ECOL168927:B0037-MONOMER    MetaCyc:CAIC-MONOMER   
KEGG: ecj:JW0036    eco:b0037   

Gene Ontology

GO:0051108 F:carnitine-CoA ligase activity
GO:0051109 F:crotonobetaine-CoA ligase activity
GO:0008152 P:metabolic process

References (7)

[1] “Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli.”  Eichler K.et.al.   7815937
[2] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.”  Yura T.et.al.   1630901
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Rates of DNA sequence evolution in experimental populations of Escherichia coli during 20,000 generations.”  Lenski R.E.et.al.   12664169
[6] “A new family of CoA-transferases.”  Heider J.et.al.   11749953
[7] “Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism.”  Stenmark P.et.al.   15518548

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDIIGGQHLR QMWDDLADVY GHKTALICES SGGVVNRYSY LELNQEINRT ANLFYTLGIR 
61:	KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLCEE SAWILQNSQA CLLVTSAQFY 
121:	PMYQQIQQED ATQLRHICLT DVALPADDGV SSFTQLKNQQ PATLCYAPPL STDDTAEILF 
181:	TSGTTSRPKG VVITHYNLRF AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG 
241:	ATFVLVEKYS ARAFWGQVQK YRATVTECIP MMIRTLMVQP PSANDQQHRL REVMFYLNLS 
301:	EQEKDAFCER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRVGFCYE AEIRDDHNRP 
361:	LPAGEIGEIC IKGIPGKTIF KEYFLNPQAT AKVLEADGWL HTGDTGYRDE EDFFYFVDRR 
421:	CNMIKRGGEN VSCVELENII AAHPKIQDIV VVGIKDSIRD EAIKAFVVLN EGETLSEEEF 
481:	FRFCEQNMAK FKVPSYLEIR KDLPRNCSGK IIRKNLK