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4.C.1.1.7
4-Coumarate CoA synthase (ligase 2) (EC 6.2.1.12)

Accession Number:Q42524
Protein Name:4-coumarate--CoA ligase 1
Length:561
Molecular Weight:61053.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: Q42524
HEGENOM: HBG547964
RefSeq: NP_175579.1    NP_849793.1   
Entrez Gene ID: 841593   
Pfam: PF00501   
BioCyc: MetaCyc:AT1G51680-MONOMER   

Gene Ontology

GO:0016207 F:4-coumarate-CoA ligase activity
GO:0005524 F:ATP binding
GO:0009698 P:phenylpropanoid metabolic process

References (9)

[1] “The Arabidopsis thaliana 4-coumarate:CoA ligase (4CL) gene: stress and developmentally regulated expression and nucleotide sequence of its cDNA.”  Lee D.et.al.   7640359
[2] “Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms.”  Ehlting J.et.al.   10417722
[3] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “Identification of 4-coumarate:coenzyme A ligase (4CL) substrate recognition domains.”  Ehlting J.et.al.   11576429
[6] “Arabidopsis contains a large superfamily of acyl-activating enzymes. Phylogenetic and biochemical analysis reveals a new class of acyl-coenzyme a synthetases.”  Shockey J.M.et.al.   12805634
[7] “The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase.”  Schneider K.et.al.   12819348
[8] “A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid.”  Schneider K.et.al.   15677481
[9] “Multiple cis-regulatory elements regulate distinct and complex patterns of developmental and wound-induced expression of Arabidopsis thaliana 4CL gene family members.”  Soltani B.M.et.al.   16738863
Structure:
3TSY     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAPQEQAVSQ VMEKQSNNNN SDVIFRSKLP DIYIPNHLSL HDYIFQNISE FATKPCLING 
61:	PTGHVYTYSD VHVISRQIAA NFHKLGVNQN DVVMLLLPNC PEFVLSFLAA SFRGATATAA 
121:	NPFFTPAEIA KQAKASNTKL IITEARYVDK IKPLQNDDGV VIVCIDDNES VPIPEGCLRF 
181:	TELTQSTTEA SEVIDSVEIS PDDVVALPYS SGTTGLPKGV MLTHKGLVTS VAQQVDGENP 
241:	NLYFHSDDVI LCVLPMFHIY ALNSIMLCGL RVGAAILIMP KFEINLLLEL IQRCKVTVAP 
301:	MVPPIVLAIA KSSETEKYDL SSIRVVKSGA APLGKELEDA VNAKFPNAKL GQGYGMTEAG 
361:	PVLAMSLGFA KEPFPVKSGA CGTVVRNAEM KIVDPDTGDS LSRNQPGEIC IRGHQIMKGY 
421:	LNNPAATAET IDKDGWLHTG DIGLIDDDDE LFIVDRLKEL IKYKGFQVAP AELEALLIGH 
481:	PDITDVAVVA MKEEAAGEVP VAFVVKSKDS ELSEDDVKQF VSKQVVFYKR INKVFFTESI 
541:	PKAPSGKILR KDLRAKLANG L