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4.C.1.1.8
Bile-acyl CoA synthetase/ Very long chain acyl CoA synthetase-related protein (Solute carrier family 27 member 5) (Gimeno, 2007)

Accession Number:Q4LDG0
Protein Name:FatP5
Length:689
Molecular Weight:76203.00
Species:Mus musculus [10090]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: Q4LDG0
eggNOG: roNOG09217
HEGENOM: HBG712034
RefSeq: NP_033538.2   
Entrez Gene ID: 26459   
Pfam: PF00501   
KEGG: mmu:26459   

Gene Ontology

GO:0009925 C:basal plasma membrane
GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0047747 F:cholate-CoA ligase activity
GO:0015245 F:fatty acid transporter activity
GO:0004467 F:long-chain-fatty-acid-CoA ligase activity
GO:0046951 P:ketone body biosynthetic process
GO:0001676 P:long-chain fatty acid metabolic process
GO:0015911 P:plasma membrane long-chain fatty acid trans...
GO:0006642 P:triglyceride mobilization

References (4)

[1] “A novel relative of the very-long-chain acyl-CoA synthetase and fatty acid transporter protein genes with a distinct expression pattern.”  Berger J.et.al.   9642112
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “A family of fatty acid transporters conserved from mycobacterium to man.”  Hirsch D.et.al.   9671728
[4] “Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.”  Mihalik S.J.et.al.   11980911

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGIWKKLTLL LLLLLLVGLG QPPWPAAMAL ALRWFLGDPT CLVLLGLALL GRPWISSWMP 
61:	HWLSLVGAAL TLFLLPLQPP PGLRWLHKDV AFTFKMLFYG LKFRRRLNKH PPETFVDALE 
121:	RQALAWPDRV ALVCTGSEGS SITNSQLDAR SCQAAWVLKA KLKDAVIQNT RDAAAILVLP 
181:	SKTISALSVF LGLAKLGCPV AWINPHSRGM PLLHSVRSSG ASVLIVDPDL QENLEEVLPK 
241:	LLAENIHCFY LGHSSPTPGV EALGASLDAA PSDPVPASLR ATIKWKSPAI FIFTSGTTGL 
301:	PKPAILSHER VIQVSNVLSF CGCRADDVVY DVLPLYHTIG LVLGFLGCLQ VGATCVLAPK 
361:	FSASRFWAEC RQHGVTVILY VGEILRYLCN VPEQPEDKIH TVRLAMGNGL RANVWKNFQQ 
421:	RFGPIRIWEF YGSTEGNVGL MNYVGHCGAV GRTSCILRML TPFELVQFDI ETAEPLRDKQ 
481:	GFCIPVEPGK PGLLLTKVRK NQPFLGYRGS QAESNRKLVA NVRRVGDLYF NTGDVLTLDQ 
541:	EGFFYFQDRL GDTFRWKGEN VSTGEVECVL SSLDFLEEVN VYGVPVPGCE GKVGMAAVKL 
601:	APGKTFDGQK LYQHVRSWLP AYATPHFIRI QDSLEITNTY KLVKSRLVRE GFDVGIIADP 
661:	LYILDNKAQT FRSLMPDVYQ AVCEGTWNL