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4.C.1.1.9
Long-chain fatty acid trans-plasma membrane translocase or trapping enzyme, FATP1 (Insulin regulated). HIt has acyl-CoA ligase activity. (Martin et al., 2000; Hatch et al., 2002). FATP1 plays a role in porcine intramuscular preadipocytes proliferation and differentiation (Chen et al. 2017).

Accession Number:Q6PCB7
Protein Name:Long-chain fatty acid transport protein 1
Length:646
Molecular Weight:71108.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: Q6PCB7 Q6PCB7
eggNOG: COG0318 COG0318
HEGENOM: HBG712034 HOG000044189
Entrez Gene ID: 376497   
Pfam: PF00501   
KEGG: hsa:376497    hsa:376497   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0016021 C:integral to membrane
GO:0000166 F:nucleotide binding
GO:0032049 P:cardiolipin biosynthetic process
GO:0006631 P:fatty acid metabolic process
GO:0015909 P:long-chain fatty acid transport
GO:0071072 P:negative regulation of phospholipid biosynthetic process
GO:0006654 P:phosphatidic acid biosynthetic process
GO:0006656 P:phosphatidylcholine biosynthetic process
GO:0006646 P:phosphatidylethanolamine biosynthetic process
GO:0006661 P:phosphatidylinositol biosynthetic process
GO:0006659 P:phosphatidylserine biosynthetic process
GO:0055085 P:transmembrane transport
GO:0005901 C:caveola
GO:0005783 C:endoplasmic reticulum
GO:0005792 C:microsome
GO:0005743 C:mitochondrial inner membrane
GO:0005886 C:plasma membrane
GO:0015245 F:fatty acid transporter activity
GO:0031957 F:very long-chain fatty acid-CoA ligase activity
GO:0033211 P:adiponectin-mediated signaling pathway
GO:0031652 P:positive regulation of heat generation
GO:0071902 P:positive regulation of protein serine/threonine kinase activity
GO:0009409 P:response to cold
GO:0032868 P:response to insulin stimulus

References (8)

[1] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression.”  Martin G.et.al.   10873384
[4] “FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells.”  Hatch G.M.et.al.   12235169
[5] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression.”  Martin G.et.al.   10873384
[8] “FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells.”  Hatch G.M.et.al.   12235169

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT ARRDLFGLSV 
61:	LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT GECWTFAQLD AYSNAVANLF 
121:	RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK AGMEAALLNV NLRREPLAFC LGTSGAKALI 
181:	FGGEMVAAVA EVSGHLGKSL IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM 
241:	DDRLFYIYTS GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG 
301:	VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR EAERRHRVRL 
361:	AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILPHVYPIR 
421:	LVKVNEDTME LLRDAQGLCI PCQAGEPGLL VGQINQQDPL RRFDGYVSES ATSKKIAHSV 
481:	FSKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY 
541:	GVAVPGVEGK AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ 
601:	KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL