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4.C.3.1.1
Peroxisomal Acyl-CoA thioesterase 5, Acot5 (2-4 putative TMSs) It has two domains: N-terminal bile acid-CoA:amino acid N-acetyl transferase domain and a C-terminal Acyl-CoA thioester hydrolase domain.

Accession Number:Q6Q2Z6
Protein Name:Acot5
Length:421
Molecular Weight:46520.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Peroxisome1
Substrate Acyl-CoA

Cross database links:

Genevestigator: Q6Q2Z6
eggNOG: roNOG10401
HEGENOM: HBG713807
Pfam: PF04775   

Gene Ontology

GO:0005829 C:cytosol
GO:0005777 C:peroxisome
GO:0004091 F:carboxylesterase activity
GO:0016290 F:palmitoyl-CoA hydrolase activity
GO:0006637 P:acyl-CoA metabolic process
GO:0001676 P:long-chain fatty acid metabolic process
GO:0032788 P:saturated monocarboxylic acid metabolic pro...
GO:0032789 P:unsaturated monocarboxylic acid metabolic p...
GO:0000038 P:very-long-chain fatty acid metabolic process

References (2)

[1] “Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.”  Westin M.A.K.et.al.   15007068
[2] “Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.”  Lee J.et.al.   17208939

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVPTVSLEPT GHSCWDEPLS IAVRGLAPEQ PVTLRTALRD EKGALFRAHA RYRADSHGEL 
61:	DLARTPALGG SFSGLEPMGL LWAMEPDRPF WRLIKRDVQT PFVVELEVLD GHEPDGGRLL 
121:	ARAVHECHFM APGVRRVPVR EGRVRATLFL PPGTGPFPGI IDLFGVGGGL LEYRASLLAG 
181:	KGFAVMALAY YKYDDLPKVI DILHLEYFEE AVTYLLSHPQ VKGPGVGLLG ISKGAELSLS 
241:	MASFLKGITA AVVINGATVN VISTLYYKEE SLPGLGMHLE RIKVTKDGFK DIIDILNVPL 
301:	EAPDQKSLIP LERSDTAFLF LVGQDDHNWK SEFYAREASK RLQAHGKEKP QIVCYPKTGH 
361:	HIEPPYIPWS IAAPHSYFDK PILLGGEPRA HAMAQVDAWQ RLQTFFHKHL SGDKRPSPAK 
421:	L