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4.C.3.1.2
Peroxisomal Acyl-CoA thioesterase-12, Acot12 (2-4 putative TMSs)

Accession Number:Q8WYK0
Protein Name:Acot12
Length:555
Molecular Weight:62034.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate Acyl-CoA

Cross database links:

Genevestigator: Q8WYK0
HEGENOM: HBG443629
RefSeq: NP_570123.1   
Entrez Gene ID: 134526   
Pfam: PF03061    PF01852   
KEGG: hsa:134526   

Gene Ontology

GO:0005829 C:cytosol
GO:0003986 F:acetyl-CoA hydrolase activity
GO:0004091 F:carboxylesterase activity
GO:0006637 P:acyl-CoA metabolic process
GO:0006631 P:fatty acid metabolic process

References (3)

[1] “Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase.”  Suematsu N.et.al.   16951743
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
Structure:
3B7K   4MOB   4MOC     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MERPAPGEVV MSQAIQPAHA TARGELSAGQ LLKWIDTTAC LAAEKHAGVS CVTASVDDIQ 
61:	FEETARVGQV ITIKAKVTRA FSTSMEISIK VMVQDMLTGI EKLVSVAFST FVAKPVGKEK 
121:	IHLKPVTLLT EQDHVEHNLA AERRKVRLQH EDTFNNLMKE SSKFDDLIFD EEEGAVSTRG 
181:	TSVQSIELVL PPHANHHGNT FGGQIMAWME TVATISASRL CWAHPFLKSV DMFKFRGPST 
241:	VGDRLVFTAI VNNTFQTCVE VGVRVEAFDC QEWAEGRGRH INSAFLIYNA ADDKENLITF 
301:	PRIQPISKDD FRRYRGAIAR KRIRLGRKYV ISHKEEVPLC IHWDISKQAS LSDSNVEALK 
361:	KLAAKRGWEV TSTVEKIKIY TLEEHDVLSV WVEKHVGSPA HLAYRLLSDF TKRPLWDPHF 
421:	VSCEVIDWVS EDDQLYHITC PILNDDKPKD LVVLVSRRKP LKDGNTYTVA VKSVILPSVP 
481:	PSPQYIRSEI ICAGFLIHAI DSNSCIVSYF NHMSASILPY FAGNLGGWSK SIEETAASCI 
541:	QFLENPPDDG FVSTF