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5.A.1.2.10
CcdA of 222 aas and 6 TMSs. The NMR structure in an oxidized and outward-facing state has been determined. CcdA consists of two inverted structural repeats of three transmembrane helices (2 x 3-TMSs). Zhou and Bushweller 2018 computationally modeled and experimentally validated an inward-facing state, which suggests that CcdA uses an elevator-type movement to shuttle the reactive cysteines across the membrane. Its structure may be relevant to other LysE superfamily transporters. Structure comparisons of CcdA, semiSWEET, Pnu, and major facilitator superfamily (MFS) transporters provide insights into membrane transporter architecture and mechanism (Zhou and Bushweller 2018).

Accession Number:Q72IT8
Protein Name:Cytochrome C-type biogenesis protein ccdA
Length:222
Molecular Weight:24044.00
Species:Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [262724]
Number of TMSs:6
Substrate

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FASTA formatted sequence
1:	MSLSLTAAFL AGVLSFLSPC VLPLVPTYLF YLGGERGRPL FNALFFILGF GAVFFLLGLP 
61:	FTLLGGLLFE HRQTLARVGG VVLVLFGLYM LGLRPRWGVS LRYEGETSRP LGAFLLGATL 
121:	ALGWTPCIGP ILGAILTLTA VGGGVGFLLA YILGLAVPFF VVALFADRIK GWLRRAGRIS 
181:	HYVEVLAGVV LVLVGVLLFT GTFTALNTFF LRITPEWLQR YL