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5.A.1.2.9
CcdA family member, the thiol:disulfide excange protein, DipZ of 695 aas and 7 TMSs.  The 1.9Å resolution x-ray structure of the C-terminal ectodomain of Rv2874 revealed the predicted thioredoxin-like domain with its conserved Cys-X-X-Cys active-site motif, but this domain is combined with a second domain with a carbohydrate-binding module (CBM) fold (Goldstone et al. 2016). A cavity in the CBM adjacent to the thioredoxin active site suggested the presence of a carbohydrate-binding site.  Possibly, this allows an expansion of the thioredoxin-domain functionality to carbohydrate modification.

Accession Number:P9WG63
Protein Name:Protein DipZ
Length:695
Molecular Weight:74168.00
Species:Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Electrons, Carbohydrates

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVESRRAAAA ASAYASRCGI APATSQRSLA TPPTISVPSG EGRCRCHVAR GAGRDPRRRL 
61:	RRRRWCGRCG YHSHLTGGEF DVNRLCQQRS RERSCQLVAV PADPRPKRQR ITDVLTLALV 
121:	GFLGGLITGI SPCILPVLPV IFFSGAQSVD AAQVAKPEGA VAVRRKRALS ATLRPYRVIG 
181:	GLVLSFGMVT LLGSALLSVL HLPQDAIRWA ALVALVAIGA GLIFPRFEQL LEKPFSRIPQ 
241:	KQIVTRSNGF GLGLALGVLY VPCAGPILAA IVVAGATATI GLGTVVLTAT FALGAALPLL 
301:	FFALAGQRIA ERVGAFRRRQ REIRIATGSV TILLAVALVF DLPAALQRAI PDYTASLQQQ 
361:	ISTGTEIREQ LNLGGIVNAQ NAQLSNCSDG AAQLESCGTA PDLKGITGWL NTPGNKPIDL 
421:	KSLRGKVVLI DFWAYSCINC QRAIPHVVGW YQAYKDSGLA VIGVHTPEYA FEKVPGNVAK 
481:	GAANLGISYP IALDNNYATW TNYRNRYWPA EYLIDATGTV RHIKFGEGDY NVTETLVRQL 
541:	LNDAKPGVKL PQPSSTTTPD LTPRAALTPE TYFGVGKVVN YGGGGAYDEG SAVFDYPPSL 
601:	AANSFALRGR WALDYQGATS DGNDAAIKLN YHAKDVYIVV GGTGTLTVVR DGKPATLPIS 
661:	GPPTTHQVVA GYRLASETLE VRPSKGLQVF SFTYG