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5.A.1.6.1
Heavy metal transport detoxicification protein (499aas; 7TMSs). Has an N-terminal heavy metal binding domain ( 70 aas) resembling MerP (1.A.72.3) and the metal binding N-terminal domains of family 5 & 6-type P-ATPases (3.A.3.5 and 3.A.3.6), a central DsbD domain and a C-terminal COG4633 domain (Gupta et al., 1997). COG4633 may also contain a metal ion binding domain homologous to but more distant in sequence from those in copper-ATPases.

Accession Number:A3DGJ1
Protein Name:Heavy metal transport/detoxification protein
Length:499
Molecular Weight:54044.00
Species:Clostridium thermocellum (strain ATCC 27405 / DSM 1237) [203119]
Number of TMSs:6
Substrate Electrons

Cross database links:

eggNOG: COG2836
HEGENOM: HBG421847
Entrez Gene ID: 4809395   
Pfam: PF02683    PF00403   
KEGG: cth:Cthe_1849   

Gene Ontology

GO:0016020 C:membrane
GO:0046872 F:metal ion binding
GO:0017004 P:cytochrome complex assembly
GO:0030001 P:metal ion transport
GO:0055114 P:oxidation-reduction process

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNNFTANKL YVQGMTCTGC ETRIENVLRK LDGVTDVKAS YTSSTVYVAY DKSKLNLDKI 
61:	IETVEKLDYK IKGVEDEKNA GYDKRENFAP ENGSKTETGQ LLGIIIVFLA FLLIIKNGRV 
121:	FNFIPEIDRS MSYGLLFVAG LLTSLHCVAM CGGINMSVCM QYKSAGGKSK ALGSSDGKTG 
181:	KAVEFEQLMP SFLYNLGRVI SYTVVGGVVG ALGSVISFSG AAKGVVAIIS GVFMVIMGLN 
241:	MLNIFPVLRK ITPRMPKIFG RKISNAKNKG PLLVGLLNGF MPCGPLQAMQ LYALGTGSFI 
301:	AGATSMFMFS LGTVPLMFGL GAISSIAGGK FTQKMMRISA VLVIVLGVVM FNRGLSLSGY 
361:	SFPIFYADSA KGASIARIEG DVQVVETQLE PGRYAPIVVQ KGIPVKWTIK ANKEDLNGCN 
421:	NAIVAREFGI DNRKLEVGDN IIEFTPAREG EFVYSCWMGM IHGYIKVVND INEIDQDDIN 
481:	LKNEGFNLNK ILPKGCCGI