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5.A.3.4.3
Biotin d-sulfoxide reductase, BisC (requires a small thioredoxin-like protein) (Pierson and Campbell, 1990)

Accession Number:P20099
Protein Name:Biotin sulfoxide reductase
Length:777
Molecular Weight:85851.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: P20099
EchoBASE: EB0122
EcoGene: EG10124
eggNOG: COG0243
HEGENOM: HBG304064
RefSeq: AP_004243.1    NP_418007.3   
Entrez Gene ID: 946915   
Pfam: PF00384    PF01568   
BioCyc: EcoCyc:EG10124-MONOMER    ECOL168927:B3551-MONOMER    MetaCyc:EG10124-MONOMER   
KEGG: ecj:JW5940    eco:b3551   

Gene Ontology

GO:0009055 F:electron carrier activity
GO:0033744 F:L-methionine-(S)-S-oxide reductase activity
GO:0030151 F:molybdenum ion binding
GO:0055114 P:oxidation reduction

References (4)

[1] “Cloning and nucleotide sequence of bisC, the structural gene for biotin sulfoxide reductase in Escherichia coli.”  Pierson D.E.et.al.   2180922
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANSSSRYSV LTAAHWGPML VETDGETVFS SRGALATGME NSLQSAVRDQ VHSNTRVRFP 
61:	MVRKGFLASP ENPQGIRGQD EFVRVSWDEA LDLIHQQHKR IREAYGPASI FAGSYGWRSN 
121:	GVLHKASTLL QRYMALAGGY TGHLGDYSTG AAQAIMPYVV GGSEVYQQQT SWPLVLEHSD 
181:	VVVLWSANPL NTLKIAWNAS DEQGLSYFSA LRDSGKKLIC IDPMRSETVD FFGDKMEWVA 
241:	PHMGTDVALM LGIAHTLVEN GWHDEAFLAR CTTGYAVFAS YLLGESDGIA KTAEWAAEIC 
301:	GVGAAKIREL AAIFHQNTTM LMAGWGMQRQ QFGEQKHWMI VTLAAMLGQI GTPGGGFGLS 
361:	YHFANGGNPT RRSAVLSSMQ GSLPGGCDAV DKIPVARIVE ALENPGGAYQ HNGMNRHFPD 
421:	IRFIWWAGGA NFTHHQDTNR LIRAWQKPEL VVISECFWTA AAKHADIVLP ATTSFERNDL 
481:	TMTGDYSNQH LVPMKQVVPP RYEARNDFDV FAELSERWEK GGYARFTEGK SELQWLETFY 
541:	NVARQRGASQ QVELPPFAEF WQANQLIEMP ENPDSERFIR FADFCRDPLA HPLKTASGKI 
601:	EIFSQRIADY GYPDCPGHPM WLEPDEWQGN AEPEQLQVLS AHPAHRLHSQ LNYSSLRELY 
661:	AVANREPVTI HPDDAQERGI QDGDTVRLWN ARGQILAGAV ISEGIKPGVI CIHEGAWPDL 
721:	DLTADGICKN GAVNVLTKDL PSSRLGNGCA GNTALAWLEK YNGPELTLTA FEPPASS