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5.B.1.1.3
Multiple tissue mitogenic oxidase, subunit 65 (Mox1 or Nox1) (alternative splicing yields a 191 aa protein with H+ channel activity) (Bánfi et al., 2000; Suh et al., 1999)

Accession Number:Q9Y5S8
Protein Name:NOX1 aka NOH1 aka Mox1
Length:564
Molecular Weight:64871.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: Q9Y5S8
HEGENOM: HBG591219
RefSeq: NP_008983.2    NP_039249.1   
Entrez Gene ID: 27035   
Pfam: PF08022    PF01794    PF08030   
OMIM: 300225  gene
KEGG: hsa:27035   

Gene Ontology

GO:0005769 C:early endosome
GO:0043020 C:NADPH oxidase complex
GO:0009055 F:electron carrier activity
GO:0050660 F:FAD binding
GO:0005506 F:iron ion binding
GO:0050661 F:NADP or NADPH binding
GO:0048365 F:Rac GTPase binding
GO:0016175 F:superoxide-generating NADPH oxidase activity
GO:0030171 F:voltage-gated proton channel activity
GO:0001525 P:angiogenesis
GO:0016477 P:cell migration
GO:0022900 P:electron transport chain
GO:0006746 P:FADH2 metabolic process
GO:0042743 P:hydrogen peroxide metabolic process
GO:0006954 P:inflammatory response
GO:0051454 P:intracellular pH elevation
GO:0006739 P:NADP metabolic process
GO:0045726 P:positive regulation of integrin biosyntheti...
GO:0048661 P:positive regulation of smooth muscle cell p...
GO:0010575 P:positive regulation vascular endothelial gr...
GO:0015992 P:proton transport
GO:0008217 P:regulation of blood pressure
GO:0045730 P:respiratory burst
GO:0009268 P:response to pH
GO:0007165 P:signal transduction
GO:0042554 P:superoxide anion generation

References (8)

[1] “Cell transformation by the superoxide-generating oxidase Mox1.”  Suh Y.-A.et.al.   10485709
[2] “A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1.”  Banfi B.et.al.   10615049
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain.”  Cheng G.et.al.   14617635
[7] “Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1.”  Park H.S.et.al.   16329988
[8] “Nox1-dependent reactive oxygen generation is regulated by Rac1.”  Cheng G.et.al.   16636067

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNWVVNHWF SVLFLVVWLG LNVFLFVDAF LKYEKADKYY YTRKILGSTL ACARASALCL 
61:	NFNSTLILLP VCRNLLSFLR GTCSFCSRTL RKQLDHNLTF HKLVAYMICL HTAIHIIAHL 
121:	FNFDCYSRSR QATDGSLASI LSSLSHDEKK GGSWLNPIQS RNTTVEYVTF TSIAGLTGVI 
181:	MTIALILMVT SATEFIRRSY FEVFWYTHHL FIFYILGLGI HGIGGIVRGQ TEESMNESHP 
241:	RKCAESFEMW DDRDSHCRRP KFEGHPPESW KWILAPVILY ICERILRFYR SQQKVVITKV 
301:	VMHPSKVLEL QMNKRGFSME VGQYIFVNCP SISLLEWHPF TLTSAPEEDF FSIHIRAAGD 
361:	WTENLIRAFE QQYSPIPRIE VDGPFGTASE DVFQYEVAVL VGAGIGVTPF ASILKSIWYK 
421:	FQCADHNLKT KKIYFYWICR ETGAFSWFNN LLTSLEQEME ELGKVGFLNY RLFLTGWDSN 
481:	IVGHAALNFD KATDIVTGLK QKTSFGRPMW DNEFSTIATS HPKSVVGVFL CGPRTLAKSL 
541:	RKCCHRYSSL DPRKVQFYFN KENF