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5.B.1.1.4
Mitogenic NADPH oxidase 3, Nox3 (Cheng et al., 2001). Critical for formation of otoconia, mineral crystals in the inner ear; mutants are defective for motion and gravity sensing (Paffenholz et al., 2004).

Accession Number:Q9HBY0
Protein Name:Nox3
Length:568
Molecular Weight:64935.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: Q9HBY0
eggNOG: prNOG06154
HEGENOM: HBG591219
RefSeq: NP_056533.1   
Entrez Gene ID: 50508   
Pfam: PF08022    PF01794    PF08030   
OMIM: 607105  gene
KEGG: hsa:50508   

Gene Ontology

GO:0009055 F:electron carrier activity
GO:0050660 F:FAD binding
GO:0005506 F:iron ion binding
GO:0055114 P:oxidation reduction

References (5)

[1] “Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.”  Cheng G.et.al.   11376945
[2] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[3] “NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells.”  Kikuchi H.et.al.   10974555
[4] “Nox3 regulation by NOXO1, p47phox, and p67phox.”  Cheng G.et.al.   15181005
[5] “The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.”  Ueno N.et.al.   15824103

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMGCWILNEG LSTILVLSWL GINFYLFIDT FYWYEEEESF HYTRVILGST LAWARASALC 
61:	LNFNCMLILI PVSRNLISFI RGTSICCRGP WRRQLDKNLR FHKLVAYGIA VNATIHIVAH 
121:	FFNLERYHWS QSEEAQGLLA ALSKLGNTPN ESYLNPVRTF PTNTTTELLR TIAGVTGLVI 
181:	SLALVLIMTS STEFIRQASY ELFWYTHHVF IVFFLSLAIH GTGRIVRGQT QDSLSLHNIT 
241:	FCRDRYAEWQ TVAQCPVPQF SGKEPSAWKW ILGPVVLYAC ERIIRFWRFQ QEVVITKVVS 
301:	HPSGVLELHM KKRGFKMAPG QYILVQCPAI SSLEWHPFTL TSAPQEDFFS VHIRAAGDWT 
361:	AALLEAFGAE GQALQEPWSL PRLAVDGPFG TALTDVFHYP VCVCVAAGIG VTPFAALLKS 
421:	IWYKCSEAQT PLKLSKVYFY WICRDARAFE WFADLLLSLE TRMSEQGKTH FLSYHIFLTG 
481:	WDENQALHIA LHWDENTDVI TGLKQKTFYG RPNWNNEFKQ IAYNHPSSSI GVFFCGPKAL 
541:	SRTLQKMCHL YSSADPRGVH FYYNKESF