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5.B.1.1.5
NADPH oxidase 5 (Nox5) (Cheng et al., 2001)

Accession Number:Q96PH1
Protein Name:Nox5
Length:765
Molecular Weight:86439.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: Q96PH1
RefSeq: NP_078781.2   
Entrez Gene ID: 79400   
Pfam: PF08022    PF01794    PF08030   
OMIM: 606572  gene
KEGG: hsa:79400   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005509 F:calcium ion binding
GO:0009055 F:electron carrier activity
GO:0050660 F:FAD binding
GO:0020037 F:heme binding
GO:0015252 F:hydrogen ion channel activity
GO:0050661 F:NADP or NADPH binding
GO:0016175 F:superoxide-generating NADPH oxidase activity
GO:0008283 P:cell proliferation
GO:0050663 P:cytokine secretion
GO:0000910 P:cytokinesis
GO:0022900 P:electron transport chain
GO:0006917 P:induction of apoptosis
GO:0006811 P:ion transport
GO:0043012 P:regulation of fusion of sperm to egg plasma...
GO:0010155 P:regulation of proton transport
GO:0042554 P:superoxide anion generation

References (8)

[1] “A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes.”  Banfi B.et.al.   11483596
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.”  Kawahara T.et.al.   15994299
[4] “Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.”  Cheng G.et.al.   11376945
[5] “NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.”  Brar S.S.et.al.   12686516
[6] “Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5).”  Banfi B.et.al.   14982937
[7] “NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.”  Cucoranu I.et.al.   16179589
[8] “Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia.”  Kamiguti A.S.et.al.   16339585

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNTSGDPAQT GPEGCRGTMS AEEDARWLRW VTQQFKTIAG EDGEISLQEF KAALHVKESF 
61:	FAERFFALFD SDRSGTITLQ ELQEALTLLI HGSPMDKLKF LFQVYDIDVC ARQGASAGTE 
121:	WGAGAGPHWA SSPLGTGSGS IDPDELRTVL QSCLRESAIS LPDEKLDQLT LALFESADAD 
181:	GNGAITFEEL RDELQRFPGV MENLTISAAH WLTAPAPRPR PRRPRQLTRA YWHNHRSQLF 
241:	CLATYAGLHV LLFGLAASAH RDLGASVMVA KGCGQCLNFD CSFIAVLMLR RCLTWLRATW 
301:	LAQVLPLDQN IQFHQLMGYV VVGLSLVHTV AHTVNFVLQA QAEASPFQFW ELLLTTRPGI 
361:	GWVHGSASPT GVALLLLLLL MFICSSSCIR RSGHFEVFYW THLSYLLVWL LLIFHGPNFW 
421:	KWLLVPGILF FLEKAIGLAV SRMAAVCIME VNLLPSKVTH LLIKRPPFFH YRPGDYLYLN 
481:	IPTIARYEWH PFTISSAPEQ KDTIWLHIRS QGQWTNRLYE SFKASDPLGR GSKRLSRSVT 
541:	MRKSQRSSKG SEILLEKHKF CNIKCYIDGP YGTPTRRIFA SEHAVLIGAG IGITPFASIL 
601:	QSIMYRHQKR KHTCPSCQHS WIEGVQDNMK LHKVDFIWIN RDQRSFEWFV SLLTKLEMDQ 
661:	AEEAQYGRFL ELHMYMTSAL GKNDMKAIGL QMALDLLANK EKKDSITGLQ TRTQPGRPDW 
721:	SKVFQKVAAE KKGKVQVFFC GSPALAKVLK GHCEKFGFRF FQENF