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5.B.2.1.3
Duodenyl cytochrome b ferrireductase, Dcytb. Duodenyl L-Ascorbate (in):Fe3+ iron chelate (out) oxidoreduclase. Present in duodenal enterocyte brush boarder membranes (isoform 1); reduces dietary Fe3+ to Fe2+ to facilitate its transport into the mucosal cell. Binds two hemes non-covalently. Induced by iron deficiency. Also expressed in erythrocytes and respiratory epithelia (Lane and Lawen, 2009).  

Accession Number:Q53TN4
Protein Name:Cytochrome b reductase 1
Length:286
Molecular Weight:31641.00
Species: [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: Q53TN4
RefSeq: NP_001120855.1    NP_079119.3   
Entrez Gene ID: 79901   
OMIM: 605745  gene
KEGG: hsa:79901   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000293 F:ferric-chelate reductase activity
GO:0046872 F:metal ion binding
GO:0022900 P:electron transport chain
GO:0006810 P:transport

References (17)

[1] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload.”  Zaahl M.G.et.al.   15338274
[6] “Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.”  Zoller H.et.al.   12949720
[7] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[8] “A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.”  Constantine C.C.et.al.   19673882
[9] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195
[10] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[11] “Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload.”  Zaahl M.G.et.al.   16521301
[12] “Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload.”  Zaahl M.G.et.al.   16521311
[13] “Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload.”  Zaahl M.G.et.al.   16521312
[14] “Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status.”  Li A.C.Y.et.al.   17087784
[15] “Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling.”  Su D.et.al.   17068337
[16] “Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.”  Turi J.L.et.al.   16510471
[17] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMEGYWRFL ALLGSALLVG FLSVIFALVW VLHYREGLGW DGSALEFNWH PVLMVTGFVF 
61:	IQGIAIIVYR LPWTWKCSKL LMKSIHAGLN AVAAILAIIS VVAVFENHNV NNIANMYSLH 
121:	SWVGLIAVIC YLLQLLSGFS VFLLPWAPLS LRAFLMPIHV YSGIVIFGTV IATALMGLTE 
181:	KLIFSLRDPA YSTFPPEGVF VNTLGLLILV FGALIFWIVT RPQWKRPKEP NSTILHPNGG 
241:	TEQGARGSMP AYSGNNMDKS DSELNSEVAA RKRNLALDEA GQRSTM