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5.B.2.1.4
Secretory vesicle-specific (chromafin granule) cytochrome b561 (isoform 2)

Accession Number:P49447
Protein Name:Cytb561
Length:251
Molecular Weight:27559.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

Genevestigator: P49447 P49447
eggNOG: prNOG08655 prNOG08655
RefSeq: NP_001017916.1    NP_001017917.1    NP_001906.3   
Entrez Gene ID: 1534   
Pfam: PF03188   
OMIM: 600019  gene
KEGG: hsa:1534    hsa:1534   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004128 F:cytochrome-b5 reductase activity
GO:0000293 F:ferric-chelate reductase activity
GO:0046872 F:metal ion binding
GO:0022900 P:electron transport chain
GO:0006810 P:transport

References (8)

[1] “Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane.”  Srivastava M.et.al.   7559396
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information.”  Srivastava M.et.al.   7980462
[5] “Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane.”  Srivastava M.et.al.   7559396
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information.”  Srivastava M.et.al.   7980462

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGGAAAATP TALPYYVAFS QLLGLTLVAM TGAWLGLYRG GIAWESDLQF NAHPLCMVIG 
61:	LIFLQGNALL VYRVFRNEAK RTTKVLHGLL HIFALVIALV GLVAVFDYHR KKGYADLYSL 
121:	HSWCGILVFV LYFVQWLVGF SFFLFPGASF SLRSRYRPQH IFFGATIFLL SVGTALLGLK 
181:	EALLFNLGGK YSAFEPEGVL ANVLGLLLAC FGGAVLYILT RADWKRPSQA EEQALSMDFK 
241:	TLTEGDSPGS Q