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8.A.1.2.1
CzcB of MFP cluster 2 (functions with RND porter CzcA, TC# 1.A.6.1.2 and CzcC, TC# 1.B.17.2.1).

Accession Number:P37973
Protein Name:CNRB aka CzcB
Length:395
Molecular Weight:40083.00
Species:Alcaligenes eutrophus (Ralstonia eutropha) [266264]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass membrane protein2
Substrate NONE

Cross database links:

eggNOG: COG0845
HEGENOM: HBG701618
RefSeq: YP_161706.1    YP_582018.1   
Entrez Gene ID: 3187388    4036647   
Pfam: PF00529   
KEGG: rme:Rmet_6209   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0008565 F:protein transporter activity
GO:0030001 P:metal ion transport
GO:0009306 P:protein secretion

References (2)

[1] “Characterization of the inducible nickel and cobalt resistance determinant cnr from pMOL28 of Alcaligenes eutrophus CH34.”  Liesegang H.et.al.   8380802
[2] “Regulation of the cnr cobalt and nickel resistance determinant from Ralstonia sp. strain CH34.”  Grass G.et.al.   10671463

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMKNERRSVN WPMIAGVAAV AAAVGFGAAH LPVSEKSPAS TQAPEAQKPQ SAPVKPGLKE 
61:	VKIPATYLAA ANIAVEPVAS AAVGTEILAP ATVAALPGSE AVIVSRAAGA VQRVQRRLGD 
121:	VVKAGDVLAL VDSPEAAGMA AERKVAQAKA DLARKTYERE ASLFQQGVTP RQEMEAAKAA 
181:	LDVAQAEALR AATVAQSAHL ASDGRSVAVV SPIAGKITAQ SVTLGAFVAP QAELFRVAGT 
241:	GAVQVEAAVT AADTSRIVAG SEATILLANG SPLSARVQAV TPTVTGSARV ATVVVVPAQP 
301:	TDRLVVGEGV QVRLRTAVAD AAALSVPEDA VQNLDGRDVL FVRTQEGFRP MPVLVGTRSG 
361:	GSAQILSGVQ AGEQVATRNA FLVKAEMNKG GGDEE