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8.A.1.4.2
Competence factor transport accessory protein, ComB

Accession Number:P36498
Protein Name:ComB aka SP0043
Length:449
Molecular Weight:49601.00
Species:Streptococcus pneumoniae [1313]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate NONE

Cross database links:

HEGENOM: HBG698298
RefSeq: NP_344592.1   
Entrez Gene ID: 929793   
KEGG: spn:SP_0043   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0030420 P:establishment of competence for transformation
GO:0006810 P:transport

References (4)

[1] “Competence for genetic transformation in Streptococcus pneumoniae: organization of a regulatory locus with homology to two lactococcin A secretion genes.”  Hui F.M.et.al.   7883181
[2] “Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.”  Tettelin H.et.al.   11463916
[3] “Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family.”  Hui F.M.et.al.   1987129
[4] “Identification of a purC gene from Streptococcus pneumoniae.”  Hui F.M.et.al.   8407811

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKPEFLESAE FYNRRYHNFS SSVIVPMALL LVFLLGFATV AEKEMSLSTR ATVEPSRILA 
61:	NIQSTSNNRI LVNHLEENKL VKKGDLLVQY QEGAEGVQAE SYASQLDMLK DQKKQLEYLQ 
121:	KSLQEGENHF PEEDKFGYQA TFRDYISQAG SLRASTSQQN ETIASQNAAA SQTQAEIGNL 
181:	ISQTEAKIRD YQTAKSAIET GASLAGQNLA YSLYQSYKSQ GEENPQTKVQ AVAQVEAQIS 
241:	QLESSLATYR VQYAGSGTQQ AYASGLSSQL ESLKSQHLAK VGQELTLLAQ KILEAESGKK 
301:	VQGNLLDKGK VTASEDGVLH LNPETSDSSM VAEGALLAQL YPSLEREGKA KLTAYLSSKY 
361:	VARIKVGDSV RYTTTHDAGN QLFLDSTITS IDATATKTEK GNFFKIEAET NLTSEQAEKL 
421:	RYGVEGRLQM ITGKKSYLRY YLDQFLNKE