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8.A.1.6.1
Acridine efflux pump constituent, AcrA

Accession Number:P0AE06
Protein Name:Acriflavine resistance protein A aka AcrA aka MTCA aka LIR aka B0463
Length:397
Molecular Weight:42197.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Lipid-anchor2
Substrate NONE

Cross database links:

Genevestigator: P0AE06
EchoBASE: EB1654
EcoGene: EG11703
eggNOG: COG0845
HEGENOM: HBG742930
DIP: DIP-29039N
RefSeq: AP_001112.1    NP_414996.1   
Entrez Gene ID: 945112   
Pfam: PF00529   
BioCyc: EcoCyc:EG11703-MONOMER    ECOL168927:B0463-MONOMER   
KEGG: ecj:JW0452    eco:b0463   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0015559 ?:?
GO:0005515 F:protein binding
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion
GO:0046677 P:response to antibiotic
GO:0042493 P:response to drug

References (6)

[1] “Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.”  Ma D.et.al.   8407802
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.”  Ma D.et.al.   7651136
[5] “Molecular construction of a multidrug exporter system, AcrAB: molecular interaction between AcrA and AcrB, and cleavage of the N-terminal signal sequence of AcrA.”  Kawabe T.et.al.   10920254
[6] “Protein complexes of the Escherichia coli cell envelope.”  Stenberg F.et.al.   16079137
Structure:
2F1M     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKNRGFTPL AVVLMLSGSL ALTGCDDKQA QQGGQQMPAV GVVTVKTEPL QITTELPGRT 
61:	SAYRIAEVRP QVSGIILKRN FKEGSDIEAG VSLYQIDPAT YQATYDSAKG DLAKAQAAAN 
121:	IAQLTVNRYQ KLLGTQYISK QEYDQALADA QQANAAVTAA KAAVETARIN LAYTKVTSPI 
181:	SGRIGKSNVT EGALVQNGQA TALATVQQLD PIYVDVTQSS NDFLRLKQEL ANGTLKQENG 
241:	KAKVSLITSD GIKFPQDGTL EFSDVTVDQT TGSITLRAIF PNPDHTLLPG MFVRARLEEG 
301:	LNPNAILVPQ QGVTRTPRGD ATVLVVGADD KVETRPIVAS QAIGDKWLVT EGLKAGDRVV 
361:	ISGLQKVRPG VQVKAQEVTA DNNQQAASGA QPEQSKS