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8.A.1.6.2
The multidrug efflux pump constituent, MdtA [may form a complex with MdtB and MdtC (2.A.6.2.12), both RND proteins. All three proteins appear to be required for resistance (Baranova and Nikaido, 2002).

Accession Number:P76397
Protein Name:Multidrug resistance protein MdtA aka MtrA
Length:415
Molecular Weight:44464.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P76397
EchoBASE: EB3809
EcoGene: EG14056
eggNOG: COG0845
HEGENOM: HBG742930
RefSeq: AP_002674.1    NP_416578.2   
Entrez Gene ID: 946604   
Pfam: PF00529   
BioCyc: EcoCyc:MDTA    ECOL168927:B2074-MONOMER   
KEGG: ecj:JW5338    eco:b2074   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion

References (5)

[1] “The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.”  Nagakubo S.et.al.   12107133
[2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.”  Itoh T.et.al.   9097040
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate.”  Baranova N.et.al.   12107134

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKGSYKSRWV IVIVVVIAAI AAFWFWQGRN DSRSAAPGAT KQAQQSPAGG RRGMRSGPLA 
61:	PVQAATAVEQ AVPRYLTGLG TITAANTVTV RSRVDGQLIA LHFQEGQQVK AGDLLAEIDP 
121:	SQFKVALAQA QGQLAKDKAT LANARRDLAR YQQLAKTNLV SRQELDAQQA LVSETEGTIK 
181:	ADEASVASAQ LQLDWSRITA PVDGRVGLKQ VDVGNQISSG DTTGIVVITQ THPIDLVFTL 
241:	PESDIATVVQ AQKAGKPLVV EAWDRTNSKK LSEGTLLSLD NQIDATTGTI KVKARFNNQD 
301:	DALFPNQFVN ARMLVDTEQN AVVIPTAALQ MGNEGHFVWV LNSENKVSKH LVTPGIQDSQ 
361:	KVVIRAGISA GDRVVTDGID RLTEGAKVEV VEAQSATTPE EKATSREYAK KGARS