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8.A.1.6.3
Multidrug resistance protein MdtE (YhiU).  Functions with MdtF (TC# 8.A.1.6.3).

Accession Number:P37636
Protein Name:Multidrug resistance protein MdtE
Length:385
Molecular Weight:41191.00
Species:Escherichia coli (strain K12) [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Lipid-anchor2
Substrate NONE

Cross database links:

Genevestigator: P37636
EchoBASE: EB2151
EcoGene: EG12240
eggNOG: COG0845
HEGENOM: HOG000158247
Entrez Gene ID: 948031   
Pfam: PF00529   
KEGG: eco:b3513   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (9)

[1] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Analysis of a complete library of putative drug transporter genes in Escherichia coli.”  Nishino K.et.al.   11566977
[5] “EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli.”  Nishino K.et.al.   11914367
[6] “Escherichia coli gene expression responsive to levels of the response regulator EvgA.”  Masuda N.et.al.   12399493
[7] “Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli.”  Eguchi Y.et.al.   14523115
[8] “Regulatory network of acid resistance genes in Escherichia coli.”  Masuda N.et.al.   12694615
[9] “Protein complexes of the Escherichia coli cell envelope.”  Stenberg F.et.al.   16079137

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRRRKLLIP LLFCGAMLTA CDDKSAENAA AMTPEVGVVT LSPGSVNVLS ELPGRTVPYE 
61:	VAEIRPQVGG IIIKRNFIEG DKVNQGDSLY QIDPAPLQAE LNSAKGSLAK ALSTASNARI 
121:	TFNRQASLLK TNYVSRQDYD TARTQLNEAE ANVTVAKAAV EQATINLQYA NVTSPITGVS 
181:	GKSSVTVGAL VTANQADSLV TVQRLDPIYV DLTQSVQDFL RMKEEVASGQ IKQVQGSTPV 
241:	QLNLENGKRY SQTGTLKFSD PTVDETTGSV TLRAIFPNPN GDLLPGMYVT ALVDEGSRQN 
301:	VLLVPQEGVT HNAQGKATAL ILDKDDVVQL REIEASKAIG DQWVVTSGLQ AGDRVIVSGL 
361:	QRIRPGIKAR AISSSQENAS TESKQ