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8.A.1.7.1
MFP, AaeA, that functions with AaeB, a γ-hydroxybenzoate efflux pump, a member of the Aromatic Acid Exporter Family (TC# 2.A.85) (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.

Accession Number:P46482
Protein Name:p-hydroxybenzoic acid efflux pump subunit aaeA
Length:310
Molecular Weight:34775.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P46482
EchoBASE: EB2674
EcoGene: EG12823
eggNOG: COG1566
HEGENOM: HBG624965
DIP: DIP-12289N
RefSeq: AP_003783.1    NP_417708.1   
Entrez Gene ID: 947748   
Pfam: PF00529   
BioCyc: EcoCyc:G7686-MONOMER    ECOL168927:B3241-MONOMER   
KEGG: ecj:JW3210    eco:b3241   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0046942 P:carboxylic acid transport
GO:0009306 P:protein secretion
GO:0042221 P:response to chemical stimulus

References (3)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?”  Van Dyk T.K.et.al.   15489430

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTLIRKFSR TAITVVLVIL AFIAIFNAWV YYTESPWTRD ARFSADVVAI APDVSGLITQ 
61:	VNVHDNQLVK KGQILFTIDQ PRYQKALEEA QADVAYYQVL AQEKRQEAGR RNRLGVQAMS 
121:	REEIDQANNV LQTVLHQLAK AQATRDLAKL DLERTVIRAP ADGWVTNLNV YTGEFITRGS 
181:	TAVALVKQNS FYVLAYMEET KLEGVRPGYR AEITPLGSNK VLKGTVDSVA AGVTNASSTR 
241:	DDKGMATIDS NLEWVRLAQR VPVRIRLDNQ QENIWPAGTT ATVVVTGKQD RDESQDSFFR 
301:	KMAHRLREFG